Seaman W J
Toxicol Pathol. 1985;13(3):177-80. doi: 10.1177/019262338501300302.
A study to determine the efficacy and safety of mibolerone following prolonged oral administration in the female dog was terminated after 9.6 yr. Histopathologic examination revealed the presence of small dense tumors in the ovaries of 12 of 92 dogs given mibolerone at the approximate efficacious dose. No such tumors were found in 60 vehicle control animals or 55 animals given exaggerated doses of mibolerone. The tumors were composed of dense fibrous connective tissue and incorporated occasional ovarian medullary tubules. The tumors appeared to grow by expansion with no evidence of invasion or metastasis and were diagnosed as fibromas.
一项旨在确定米勃酮对雌性犬长期口服给药的有效性和安全性的研究在9.6年后终止。组织病理学检查显示，在以近似有效剂量给予米勃酮的92只犬中，有12只犬的卵巢出现了小的致密肿瘤。在60只赋形剂对照动物或55只给予过量米勃酮的动物中未发现此类肿瘤。这些肿瘤由致密的纤维结缔组织组成，并偶尔包含卵巢髓质小管。肿瘤似乎通过扩张生长，没有侵袭或转移的迹象，被诊断为纤维瘤。
