Lv Shuang, Luo Chunxia
Department of Psychiatry, The Psychiatric Hospital of Guangzhou Civil Administration Bureau, Guangzhou, Guangdong 510430, P.R. China.
Int J Mol Med. 2025 Oct;56(4). doi: 10.3892/ijmm.2025.5594. Epub 2025 Jul 25.
The present review explored the emerging role of blood‑brain barrier (BBB) dysfunction in schizophrenia. Findings from biochemical markers, neuroimaging, genetic studies and experimental models are integrated to examine the impact of BBB dysfunction on the development and progression of schizophrenia. Additionally, the mechanisms by which BBB dysfunction exacerbates the schizophrenia were examined, including disruptions in cerebral blood flow, the facilitation of neuroinflammation and alterations in neurotransmitter systems. Finally, the potential for integrating BBB‑targeted interventions into broader therapeutic strategies for schizophrenia were discussed, with the goal of improving drug efficacy and minimizing side effects in clinical practice.
本综述探讨了血脑屏障（BBB）功能障碍在精神分裂症中日益凸显的作用。整合了来自生化标志物、神经影像学、遗传学研究及实验模型的研究结果，以检验BBB功能障碍对精神分裂症发生发展的影响。此外，还研究了BBB功能障碍加剧精神分裂症的机制，包括脑血流中断、神经炎症的促进及神经递质系统的改变。最后，讨论了将针对BBB的干预措施纳入更广泛的精神分裂症治疗策略的可能性，目标是在临床实践中提高药物疗效并将副作用降至最低。
