Mirkovic Nikola, Prokic Marko, Prodanovic Nikola, Nikolic Turnic Tamara, Andric Nikola, Prodanovic Tijana, Arsenijevic Neda, Simic Ivan, Knezevic Dragan, Matic Aleksandar
Vascular Surgery Center, University Clinical Center Kragujevac, Zmaj Jovina 30, 34000 Kragujevac, Serbia.
Department of Surgery, Faculty of Medical Science, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia.
Diseases. 2025 Jul 18;13(7):226. doi: 10.3390/diseases13070226.
Primary extracranial vertebral artery aneurysms are sporadic in the general population. They are uncommon in individuals with neurofibromatosis type 1. During pregnancy or in the puerperium, the risk of aneurysm rupture in individuals with neurofibromatosis type 1 and extracranial aneurysms is elevated. Rupture of a vertebral artery aneurysm is an emergency condition and can be fatal.
We present the case of a 33-year-old woman in the puerperium with neurofibromatosis type 1 who had a vertebral symptomatic artery aneurysm. During a previous hospitalization, two months before the treatment of the vertebral aneurysm, a same-sided aneurysm of the thyrocervical trunk was successfully treated with endovascular coiling because of aneurysm rupture. In this case report, the vertebral artery aneurysm was successfully managed using a flow diverter stent graft.
This is the first reported case of a successfully treated symptomatic vertebral artery aneurysm with a flow diverter stent graft in a patient with neurofibromatosis type 1 during the early puerperium. Endovascular treatment with a stent graft is a minimally invasive, safe, and effective treatment for patients with vertebral artery aneurysms. Early diagnosis of non-ruptured vertebral artery aneurysms is a crucial as well as appropriate treatment, which should be undertaken in a timely manner to prevent serious complications or a fatal outcome.
原发性颅外椎动脉动脉瘤在普通人群中较为散发性。在1型神经纤维瘤病患者中并不常见。在妊娠或产褥期，1型神经纤维瘤病合并颅外动脉瘤的患者动脉瘤破裂风险会升高。椎动脉动脉瘤破裂是一种紧急情况，可能会致命。
我们报告了一例33岁产褥期1型神经纤维瘤病女性患者，其患有有症状的椎动脉动脉瘤。在之前的一次住院期间，即在椎动脉动脉瘤治疗前两个月，患者因甲状颈干同侧动脉瘤破裂，成功接受了血管内栓塞治疗。在本病例报告中，椎动脉动脉瘤通过血流导向支架植入术成功得到治疗。
这是首次报道在产褥早期1型神经纤维瘤病患者中使用血流导向支架植入术成功治疗有症状椎动脉动脉瘤的病例。血管内支架植入治疗对椎动脉动脉瘤患者来说是一种微创、安全且有效的治疗方法。未破裂椎动脉动脉瘤的早期诊断至关重要，同时应及时进行恰当治疗，以预防严重并发症或致命后果。
