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热敏水凝胶的全面综述：作用机制、优化策略及应用

A Comprehensive Review of Thermosensitive Hydrogels: Mechanism, Optimization Strategies, and Applications.

作者信息

Lv Tianyang, Chen Yuzhu, Li Ning, Liao Xiaoyu, Heng Yumin, Guo Yayuan, Hu Kaijin

机构信息

Xian Key Laboratory for the Prevention and Control of Stomatognathic System Disorders, School of Stomatology, Xi'an Medical University, Xi'an 710021, China.

Research Center of Dental and Maxillofacial Tissue Regeneration and Repair Technology, School of Stomatology, Xi'an Medical University, Xi'an 710021, China.

出版信息

Gels. 2025 Jul 14;11(7):544. doi: 10.3390/gels11070544.

DOI:10.3390/gels11070544
PMID:40710706
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12294456/
Abstract

Thermosensitive hydrogels undergo reversible sol-gel phase transitions in response to changes in temperature. Owing to their excellent biocompatibility, mild reaction conditions, and controllable gelation properties, these hydrogels represent a promising class of biomaterials suitable for minimally invasive treatment systems in diverse biomedical applications. This review systematically summarizes the gelation mechanisms of thermosensitive hydrogels and optimization strategies to enhance their performance for broader application requirements. In particular, we highlight recent advances in injectable thermosensitive hydrogels as a carrier within stem cells, bioactive substances, and drug delivery for treating various tissue defects and diseases involving bone, cartilage, and other tissues. Furthermore, we propose challenges and directions for the future development of thermosensitive hydrogels. These insights provide new ideas for researchers to explore novel thermosensitive hydrogels for tissue repair and disease treatment.

摘要

热敏水凝胶会随着温度变化发生可逆的溶胶-凝胶相变。由于其具有出色的生物相容性、温和的反应条件以及可控的凝胶化特性，这些水凝胶代表了一类很有前景的生物材料，适用于各种生物医学应用中的微创治疗系统。本综述系统地总结了热敏水凝胶的凝胶化机制以及优化策略，以提高其性能以满足更广泛的应用需求。特别地，我们重点介绍了可注射热敏水凝胶作为干细胞、生物活性物质载体以及用于治疗涉及骨骼、软骨和其他组织的各种组织缺损和疾病的药物递送方面的最新进展。此外，我们提出了热敏水凝胶未来发展面临的挑战和方向。这些见解为研究人员探索用于组织修复和疾病治疗的新型热敏水凝胶提供了新思路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fd9/12294456/b79db906a016/gels-11-00544-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fd9/12294456/88c2187cc63d/gels-11-00544-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fd9/12294456/cd173e6aac4e/gels-11-00544-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fd9/12294456/6492b333ca09/gels-11-00544-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fd9/12294456/20747243fddc/gels-11-00544-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fd9/12294456/f3675b1a5a60/gels-11-00544-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fd9/12294456/729f6f8cc51f/gels-11-00544-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fd9/12294456/adb9a0e31c2f/gels-11-00544-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fd9/12294456/64bdb47e722c/gels-11-00544-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fd9/12294456/1404f5fe8d28/gels-11-00544-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fd9/12294456/b79db906a016/gels-11-00544-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fd9/12294456/88c2187cc63d/gels-11-00544-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fd9/12294456/cd173e6aac4e/gels-11-00544-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fd9/12294456/6492b333ca09/gels-11-00544-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fd9/12294456/20747243fddc/gels-11-00544-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fd9/12294456/f3675b1a5a60/gels-11-00544-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fd9/12294456/729f6f8cc51f/gels-11-00544-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fd9/12294456/adb9a0e31c2f/gels-11-00544-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fd9/12294456/64bdb47e722c/gels-11-00544-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fd9/12294456/1404f5fe8d28/gels-11-00544-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fd9/12294456/b79db906a016/gels-11-00544-g010.jpg

相似文献

[1]
A Comprehensive Review of Thermosensitive Hydrogels: Mechanism, Optimization Strategies, and Applications.

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[2]
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[7]
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[8]
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[9]
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[10]
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本文引用的文献

[1]
Nasal Delivery of Engineered Exosomes via a Thermo-Sensitive Hydrogel Depot Reprograms Glial Cells for Spinal Cord Repair.

Adv Sci (Weinh). 2025-6-20

[2]
Chitosan-Based Gel Development: Extraction, Gelation Mechanisms, and Biomedical Applications.

Gels. 2025-4-6

[3]
High-efficiency antioxidant ROS-responsive thermosensitive hydrogel encapsulated Fenofibrate for the treatment of corneal neovascularization.

J Control Release. 2025-6-10

[4]
Responsive Microneedles for Diagnostic and Therapeutic Applications of Ocular Diseases.

Small Methods. 2025-7

[5]
Active microneedle patch equipped with spontaneous bubble generation for enhanced rheumatoid arthritis treatment.

Theranostics. 2025-2-24

[6]
Effect of adipose-derived stem cells exosomes cross-linked chitosan-αβ-glycerophosphate thermosensitive hydrogel on deep burn wounds.

World J Stem Cells. 2025-2-26

[7]
Advances in 3D and 4D Printing of Gel-Based Foods: Mechanisms, Applications, and Future Directions.

Gels. 2025-1-27

[8]
Skin-inspired polysaccharide-based hydrogels with tailored properties for information transmission application.

Int J Biol Macromol. 2025-5

[9]
Engineering Multiresponsive Alginate/PNIPAM/Carbon Nanotube Nanocomposite Hydrogels as On-Demand Drug Delivery Platforms.

Small. 2025-3

[10]
Injectable Nanocomposite Hydrogel for Accelerating Diabetic Wound Healing Through Inflammatory Microenvironment Regulation.

Int J Nanomedicine. 2025-2-6

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