Wang Jin, Huang Lianghui, Wu Enguang, Li Xiao, Rao Yi, Zhu Caiqing
Nanchang Key Laboratory for Quality Evaluation of Medical Devices, Jiangxi Medical Device Testing Center, Nanchang 330001, China.
National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Chinese Medicine, Nanchang 330006, China.
Biology (Basel). 2025 May 27;14(6):619. doi: 10.3390/biology14060619.
Thermosensitive hydrogel, as a smart polymer material, showed great potential for application in the field of wound repair due to its unique external temperature responsiveness and excellent biocompatibility. Chitosan, a natural macromolecular polysaccharide derived from the deacetylation of chitin, possessed not only strong interactions with biomolecules such as DNA, proteins, and lipids, but also unique biocompatibility and degradability. Chitosan-based thermosensitive hydrogels, prepared by compounding chitosan with surfactants, underwent sol-gel phase transitions at varying external temperatures, which provided an ideal healing environment for wounds. This comprehensive review was initiated by elucidating the sol-gel phase transformation mechanism underlying thermosensitive hydrogels and the intricate process of wound repair. In addition, this review provided a detailed overview of the prevalent types of chitosan-based thermosensitive hydrogels, highlighting their unique characteristics and applications in different types of wound repair. Finally, the challenges and development directions of chitosan-based thermosensitive hydrogels in wound repair were discussed, aiming to provide theoretical support and practical guidance for their future applications in wound healing.
热敏水凝胶作为一种智能高分子材料,因其独特的外部温度响应性和优异的生物相容性,在伤口修复领域显示出巨大的应用潜力。壳聚糖是一种由甲壳素脱乙酰化得到的天然大分子多糖,不仅与DNA、蛋白质和脂质等生物分子有很强的相互作用,还具有独特的生物相容性和可降解性。通过将壳聚糖与表面活性剂复合制备的基于壳聚糖的热敏水凝胶,在不同的外部温度下会发生溶胶-凝胶相变,这为伤口提供了理想的愈合环境。本综述首先阐明了热敏水凝胶的溶胶-凝胶相变机制以及复杂的伤口修复过程。此外,本综述详细概述了基于壳聚糖的热敏水凝胶的常见类型,突出了它们的独特特性以及在不同类型伤口修复中的应用。最后,讨论了基于壳聚糖的热敏水凝胶在伤口修复中的挑战和发展方向,旨在为其未来在伤口愈合中的应用提供理论支持和实践指导。