Aravena Pedro Christian, Flores Mario E, Turones Larissa Córdova, Pavicic Francisca, Ehrenfeld Pamela
School of Dentistry, Faculty of Medicine, Universidad Austral de Chile, Valdivia 5090000, Chile.
Polymers Laboratory, Institute of Chemistry Sciences, Faculty of Sciences, Universidad Austral de Chile, Valdivia 5090000, Chile.
Reports (MDPI). 2025 Jun 9;8(2):92. doi: 10.3390/reports8020092.
To describe the effectiveness of alveolar ridge preservation under the radiological and histological analysis of a customized resorbable scaffold three-dimensionally printed with polycaprolactone (PCL) reinforced with a coating of a copolymer of polycaprolactone-block-polyethylene glycol (PCL-PEG) by electrospray. A 62-year-old male with vertical root fractures of teeth #14 and #15. From the cone beam CT (CBCT) image, the scaffold root replicas were designed with the shape of the roots and printed with PCL coated with PCL-PEG by electrospray. The scaffold was inserted into the alveolar bone and maintained with a tension-free flap closure. After six months, a CBCT of the surgical site and histological analysis of a bone sample at the dental implant installation site were performed. After 6 months, the wound in tooth #14 was closed, clinically proving no adverse reaction or complications. The histological analysis of the bone sample showed new bone formation with lamellar structure, Haversian canal structure, and osteocyte spaces. However, the scaffold in tooth #15 was exposed and not osseointegrated, and it was covered with membranous tissue. Histologically, the sample showed tissue compatible with lax connective tissue with mixed inflammatory infiltrate. In tooth #14, the dental implant presented an insertion torque >35 Ncm and was rehabilitated three months after its installation. Three-dimensional printed PCL scaffolds showed the ability to regenerate vital and functional bone with osseointegration capability for maxillary bone regeneration and oral rehabilitation based on dental implants. A case of inadequate scaffold osseointegration accompanied by lax connective tissue formation is shown.
通过对三维打印定制可吸收支架进行放射学和组织学分析，描述聚己内酯（PCL）增强型聚己内酯-聚乙二醇共聚物（PCL-PEG）涂层电喷雾打印的牙槽嵴保存效果。一名62岁男性，14号和15号牙垂直根折。根据锥形束CT（CBCT）图像，设计出与牙根形状相同的支架牙根复制品，并用PCL-PEG涂层的PCL通过电喷雾打印。将支架插入牙槽骨，采用无张力瓣关闭术进行维持。六个月后，对手术部位进行CBCT检查，并对牙种植体植入部位的骨样本进行组织学分析。6个月后，14号牙伤口愈合，临床证明无不良反应或并发症。骨样本的组织学分析显示有新骨形成，具有板层结构、哈弗斯管结构和骨细胞间隙。然而，15号牙的支架暴露且未骨整合，表面覆盖有膜性组织。组织学上，样本显示为与伴有混合性炎症浸润的疏松结缔组织相容的组织。在14号牙，牙种植体的植入扭矩>35 Ncm，并在植入后三个月进行了修复。三维打印的PCL支架显示出能够再生有活力和功能的骨组织，并具有骨整合能力，可用于上颌骨再生和基于牙种植体的口腔修复。展示了一例支架骨整合不足并伴有疏松结缔组织形成的病例。
