Efthimiou Ioanna, Dormousoglou Margarita, Giova Lambrini, Vlastos Dimitris, Dailianis Stefanos, Antonopoulou Maria, Konstantinou Ioannis
Department of Biology, School of Natural Sciences, University of Patras, GR-26500 Patras, Greece.
Department of Sustainable Agriculture, School of Agricultural Sciences, University of Patras, GR-30131 Agrinio, Greece.
Toxics. 2025 Jul 12;13(7):582. doi: 10.3390/toxics13070582.
Waste tires (WTs) constitute a potentially significant source of pollution, and the large quantities that are disposed of require proper handling. Pyrolysis has emerged as an environmentally friendly and effective method for WT treatment. In the present study, the cyto-genotoxic and toxic effects of untreated and acid-treated pyrolytic tire char (PTC and PTC, respectively) were investigated. The cytokinesis block micronucleus (CBMN) assay, using human lymphocytes, and the bioluminescence assay were used for the assessment of cyto-genotoxicity and ecotoxicity, respectively. According to the results, both PTC and PTC exhibited genotoxicity at all concentrations tested (2.5, 5, and 10 μg mL), which was more pronounced in the case of PTC. Cytotoxicity induction was reported for PTC and PTC at all concentrations. Both demonstrated a relatively low potential for ecotoxicity induction against . Since the cyto-genotoxic and toxic effects of PTC seemed to be more pronounced, the toxic profile of tire char should be investigated in depth before selecting the appropriate applications, thereby avoiding detrimental effects in the environment and humans alike.
废旧轮胎是一个潜在的重大污染源，大量废旧轮胎的处置需要妥善处理。热解已成为一种环保且有效的废旧轮胎处理方法。在本研究中，分别对未经处理和经酸处理的热解轮胎炭（分别为PTC和PTC）的细胞遗传毒性和毒性作用进行了研究。使用人淋巴细胞的胞质分裂阻滞微核（CBMN）试验和生物发光试验分别用于评估细胞遗传毒性和生态毒性。根据结果，PTC和PTC在所有测试浓度（2.5、5和10μg/mL）下均表现出遗传毒性，PTC的情况更为明显。在所有浓度下，PTC和PTC均有细胞毒性诱导作用。两者对……的生态毒性诱导潜力相对较低。由于PTC的细胞遗传毒性和毒性作用似乎更为明显，在选择合适的应用之前，应深入研究轮胎炭的毒性特征，从而避免对环境和人类产生有害影响。
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