Chen Yali, Ji Gaili, Hu Peishan, Xiang Rong
Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, China.
Department of Gynecology, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Trends Cell Biol. 2025 Aug;35(8):637-640. doi: 10.1016/j.tcb.2025.07.003. Epub 2025 Jul 24.
Colorectal cancer (CRC) metastasis is driven by phenotypic plasticity beyond classic epithelial-mesenchymal transition (EMT), including non-canonical lineages such as squamous-like phenotypes. Their regulatory mechanisms and clinical significance remain unclear. In the current issue of Nature, Cammareri et al. identified ATRX loss as a driver of multilineage plasticity, including squamous-like characteristics, linked to increased metastasis and poor clinical outcomes in CRC.
结直肠癌（CRC）转移是由超越经典上皮-间质转化（EMT）的表型可塑性驱动的，包括非典型谱系，如鳞状样表型。它们的调控机制和临床意义仍不清楚。在本期《自然》杂志中，卡马雷里等人确定了ATRX缺失是多谱系可塑性的驱动因素，包括鳞状样特征，这与CRC转移增加和临床预后不良有关。
