Dresse Menayit Tamrat, Ferreira Pamela C L, Prasadan Akshay, Diaz Jihui L, Zeng Xuemei, Bellaver Bruna, Povala Guilherme, Villemagne Victor L, Kamboh M Ilyas, Cohen Ann D, Pascoal Tharick A, Ganguli Mary, Snitz Beth E, Shaaban C Elizabeth, Karikari Thomas K
Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Department of Psychiatry, School of Medicine, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, PA, 15213, USA.
Alzheimers Res Ther. 2025 Jul 25;17(1):173. doi: 10.1186/s13195-025-01803-w.
Using the ATN framework, we evaluated the potential of plasma biomarkers to identify abnormal brain amyloid-beta (Aβ) positron emission tomography (PET), tau-PET and neurodegeneration in a socioeconomically disadvantaged population-based cohort.
Community-dwelling dementia-free (n = 113, including 102 (91%) cognitively normal) participants underwent ATN neuroimaging and plasma biomarker assessments.
Plasma Aβ42/Aβ40, p-tau181, and p-tau217 showed significant associations with Aβ-PET status, (adjusted odds ratio [AOR] of 1.7410, 1.47, and 3.4310, respectively (p-values < 0.05), with p-tau217 demonstrating the highest classification accuracy for Aβ-PET status (AUC = 0.94). Plasma p-tau181 and p-tau217 showed significant associations with tau-PET status (AOR: 1.50 and 22.24, respectively (p-values < 0.05), with comparable classification accuracies for tau-PET status (AUC = 0.74 and 0.70, respectively). Only plasma NfL showed significant association with neurodegeneration based on cortical thickness (AOR = 1.09, p-value < 0.05).
Our findings highlight the potential of plasma p-tau217 as a biomarker for brain Aβ and tau pathophysiology, p-tau181 for tau abnormalities, and NfL for neurodegeneration in the community.
我们使用ATN框架，在一个社会经济地位不利的人群队列中，评估了血浆生物标志物识别异常脑淀粉样β蛋白（Aβ）正电子发射断层扫描（PET）、tau-PET和神经退行性变的潜力。
居住在社区且无痴呆症的参与者（n = 113，包括102名（91%）认知正常者）接受了ATN神经影像学和血浆生物标志物评估。
血浆Aβ42/Aβ40、p-tau181和p-tau217与Aβ-PET状态显示出显著相关性（调整后的优势比[AOR]分别为1.74×10、1.47和3.43×10（p值<0.05）），其中p-tau217对Aβ-PET状态的分类准确性最高（曲线下面积[AUC]=0.94）。血浆p-tau181和p-tau217与tau-PET状态显示出显著相关性（AOR分别为1.50和22.24（p值<0.05）），对tau-PET状态的分类准确性相当（AUC分别为0.74和0.70）。仅血浆神经丝轻链（NfL）与基于皮质厚度的神经退行性变显示出显著相关性（AOR = 1.09，p值<0.05）。
我们的研究结果突出了血浆p-tau217作为脑Aβ和tau病理生理学生物标志物、p-tau181作为tau异常生物标志物以及NfL作为社区神经退行性变生物标志物的潜力。
