Tov N L, Valentik M F, Vakulin G M, Kagalovskaia I M, Sasin A V
Ter Arkh. 1985;57(6):32-6.
A total of 179 patients with chronic glomerulonephritis were examined for the development of the tubulo-interstitial component (TIC) of the disease. It was established that the rate of the development and intensity of the TIC are linked with different morphological variants of GN and increase successively in mesangiomembranous, membranous, mesangioproliferative, mesangiocapillary (and lobular) GN, reaching a maximum in diffuse fibroplastic GN. In patients with no TIC, the hematuric and latent forms of CGN were mostly encountered. The disease took a stable course, with a frequent occurrence of improvements and remission. The 5-year survival was 100%. In patients with a moderate TIC, the nephrotic form of CGN was encountered more often than in other patients. As regards other characteristics, this form occupied an intermediate position, with the 5-year survival rate amounting to 91%. Patients with a pronounced TIC were marked by progressive CGN, which was largely observed in the hypertonic and mixed patterns of the disease. The three-year survival amounted to 34% in this case. The TIC of CGN is an important prognostic factor and the dissimilar course of different morphological variants of CGN is accounted, to a considerable degree, for by the dissimilar rate of TIC development.
共对179例慢性肾小球肾炎患者进行了疾病肾小管间质成分（TIC）发展情况的检查。结果表明，TIC的发展速度和强度与肾小球肾炎（GN）的不同形态学变体相关，并在系膜膜性、膜性、系膜增生性、系膜毛细血管性（和小叶性）GN中依次增加，在弥漫性纤维增生性GN中达到最大值。在无TIC的患者中，以血尿型和隐匿型慢性肾小球肾炎（CGN）最为常见。疾病呈稳定病程，常有病情改善和缓解。5年生存率为100%。在TIC中度的患者中，CGN的肾病型比其他患者更常见。在其他特征方面，该型处于中间位置，5年生存率为91%。TIC明显的患者以进行性CGN为特征，在疾病的高血压型和混合型中较为常见。在这种情况下，三年生存率为34%。CGN的TIC是一个重要的预后因素，CGN不同形态学变体的不同病程在很大程度上是由TIC发展速度的不同所致。
