[The role of tubular interstitial changes in the genesis of the rapid progression of chronic glomerulonephritis].

The observation over 146 cases of compensated chronic glomerulonephritis (CGN) led the authors to the conclusion that there is a relationship between rapidly progressive CGN, onset of chronic renal failure 5 years after CGN diagnosis, the existence of tubulointerstitial changes (TIC) and CGN clinical pattern. Rapidly progressive CGN seems to arise primarily against TIC, in active nephritic and nephrotic-hypertensive types. In these clinical types CGN occurred more often than in TIC, while the disease takes a more favourable course in the alternative clinical types than in TIC absence. Thus, a clinical type appeared more reliable predictor of rapidly progressive CGN than TIC. The relations between clinical types and TIC explain more frequent occurrence of rapidly progressive CGN in the presence of the above morphological changes.