Torrini Luisa, Diaco Fabiana, Viscido Agnese, Sacco Federica, Sfara Germana, Compagnino Daniele Emanuele, Puggioni Gianluca, Coletti Monica, Antonelli Guido, Raponi Giammarco
Department of Molecular Medicine, Sapienza University of Rome, Italy.
Department of Molecular Medicine, Sapienza University of Rome, Italy.
Diagn Microbiol Infect Dis. 2025 Nov;113(3):117014. doi: 10.1016/j.diagmicrobio.2025.117014. Epub 2025 Jul 18.
Clostridioides difficile infection (CDI) is one of the most common healthcare-associated infections, contributing to significant morbidity and mortality, particularly in hospitalized patients. Its incidence is influenced by infection control measures, antimicrobial stewardship, and hospital hygiene protocols. The Coronavirus disease 2019 (COVID-19) pandemic led to the widespread adoption of stringent infection prevention strategies. These measures may have influenced the incidence of CDI. At the university hospital Policlinico Umberto I in Rome, we conducted a retrospective analysis of CDI cases across three periods: preCOVID-19, COVID-19 and postCOVID-19. Our findings revealed a statistically significant decrease in CDI cases during the COVID-19 period compared to the preCOVID-19 period, as well as in the postCOVID-19 period compared to the COVID-19 period. Additionally, we explored the potential association between CDI and multidrug-resistant organisms (MDRO). Our findings indicate a reduction in MDRO infections among patients with CDI in the COVID-19 and postCOVID-19 periods compared to the preCOVID-19 period. These results highlight the potential impact of infection control strategies on CDI incidence and suggest a possible relationship between CDI and MDRO infection. Further research is needed to assess the long-term effects of these measures and their implications for future infection prevention strategies.
艰难梭菌感染（CDI）是最常见的医疗保健相关感染之一，会导致严重的发病率和死亡率，尤其是在住院患者中。其发病率受感染控制措施、抗菌药物管理以及医院卫生规程的影响。2019年冠状病毒病（COVID-19）大流行导致广泛采用严格的感染预防策略。这些措施可能影响了CDI的发病率。在罗马的翁贝托一世综合医院，我们对三个时期的CDI病例进行了回顾性分析：COVID-19之前、COVID-19期间和COVID-19之后。我们的研究结果显示，与COVID-19之前的时期相比，COVID-19期间的CDI病例有统计学意义的下降，与COVID-19期间相比，COVID-19之后的时期也有下降。此外，我们探讨了CDI与多重耐药菌（MDRO）之间的潜在关联。我们的研究结果表明，与COVID-19之前的时期相比，COVID-19期间和COVID-19之后的时期CDI患者中的MDRO感染有所减少。这些结果突出了感染控制策略对CDI发病率的潜在影响，并表明CDI与MDRO感染之间可能存在关联。需要进一步研究来评估这些措施的长期影响及其对未来感染预防策略的意义。
