Karkoutly Mawia, Abu Hasna Amjad, Nam Ok Hyung, Machado Ricardo, Al Kurdi Saleh, Bshara Nada
Department of Pediatric Dentistry, Faculty of Dentistry, Damascus University, Damascus, Syrian Arab Republic.
Department of Restorative Dentistry, Endodontics Division, Institute of Science and Technology, São Paulo State University (ICT-UNESP) Eng. Francisco José Longo Avenue 777, São José dos Campos, São Paulo, Brazil.
BDJ Open. 2025 Jul 25;11(1):69. doi: 10.1038/s41405-025-00356-2.
Sodium hypochlorite (NaOCl) gel is an effective additive for white mineral trioxide aggregate (WMTA) that enhances its chemical and physical characteristics and significantly reduces setting time while maintaining biocompatibility. The study sought to compare the outcomes of pulpotomies performed in primary teeth using WMTA mixed with 2.25% NaOCl gel or WMTA mixed with distilled water (DW).
It was a randomized, triple-blinded, split-mouth, controlled clinical trial. Forty primary second molars from cooperative children aged 5-10 who required pulpotomy were randomly assigned to the control group-WMTA + DW or experimental group-WMTA + NaOCl gel for clinical and radiographic assessments at 3, 6, and 12 months of follow-up. The clinical evaluation involved checking for spontaneous pain, pain on percussion, tooth mobility, abscesses, sinus tracts, and the exfoliation of the treated tooth. The periapical radiographic evaluation identified whether there was furcal radiolucency, internal or external root resorption, and widening of the periodontal ligament. Canal obliteration was not considered a failure.
The WMTA + NaOCl gel group showed a 90% and 95% clinical and radiographical success rate, respectively, at 3, 6, and 12 months of follow-up. In the control group, the clinical success rate was 90% after 3, 6, and 12 months, whereas the radiographical success rate was 100% at 3 months and decreased to 95% after 6 and to 85% after 12 months. No statistically significant difference was detected between the two groups (p > 0.05).
The present research validated WMTA + NaOCl gel as a potentially effective material for pulpotomy in primary molars.
次氯酸钠（NaOCl）凝胶是白色矿物三氧化物聚合体（WMTA）的一种有效添加剂，可增强其化学和物理特性，并在保持生物相容性的同时显著缩短凝固时间。本研究旨在比较使用与2.25% NaOCl凝胶混合的WMTA或与蒸馏水（DW）混合的WMTA对乳牙进行牙髓切断术的效果。
这是一项随机、三盲、双侧、对照临床试验。从5至10岁需要进行牙髓切断术的合作儿童中选取40颗乳牙第二磨牙，随机分为对照组（WMTA + DW）或试验组（WMTA + NaOCl凝胶），在随访3、6和12个月时进行临床和影像学评估。临床评估包括检查自发痛、叩痛、牙齿松动度、脓肿、窦道以及治疗牙齿的脱落情况。根尖影像学评估确定是否存在根分叉透射区、牙根内或外吸收以及牙周膜增宽。根管闭塞不被视为失败。
在随访3、6和12个月时，WMTA + NaOCl凝胶组的临床成功率和影像学成功率分别为90%和95%。在对照组中，3、6和12个月后的临床成功率为90%，而影像学成功率在3个月时为100%，6个月后降至95%，12个月后降至85%。两组之间未检测到统计学上的显著差异（p > 0.05）。
本研究验证了WMTA + NaOCl凝胶作为乳牙牙髓切断术潜在有效材料的有效性。
