Ghavamikia Nima, Sahebjam Mohammad, Davarpasand Tahereh, Jenab Yaser
Cardiovascular Research Institute, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
Biomark Med. 2025 Aug;19(15):667-675. doi: 10.1080/17520363.2025.2538425. Epub 2025 Jul 27.
Inflammatory markers are associated with the severity of disease and outcomes in rheumatic mitral stenosis (RMS). This study explored the connection between newer inflammatory indices - specifically, the systemic immune inflammation index (SII) and systemic inflammation response index (SIRI) - and clinical outcomes in RMS patients who underwent percutaneous balloon mitral valvuloplasty (PBMV).
A total of 131 patients with severe RMS who received PBMV at Tehran Heart Center between August 2015 and February 2021 were assessed. Inflammatory markers were measured prior to the procedure. Echocardiographic parameters, Wilkins scores, and complications were analyzed over a three-year follow-up period. ROC curves and multivariate logistic regression were employed to evaluate predictive associations.
The average age of participants was 47.9 years, and 79.4% were female. Lower systolic pulmonary pressure and younger age were associated with a greater success rate of PBMV. Frequent complications included mitral regurgitation (47.5%) and readmission (27.5%). Higher levels of NLR, MLR, SII, and SIRI were correlated with increased Wilkins scores. SIRI was an independent predictor of PBMV success.
SIRI demonstrated the highest predictive capability for PBMV success, with 71% sensitivity and 80% specificity. It was also associated with complications and mid-term outcomes in severe RMS.
