Alheggi Ashjan
Department of Dermatology, College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh P.O. Box 7544, Saudi Arabia.
Oxf Med Case Reports. 2025 Jul 27;2025(7):omaf106. doi: 10.1093/omcr/omaf106. eCollection 2025 Jul.
Langerhans cell histiocytosis (LCH) is an inflammatory clonal proliferative neoplasm of immature myeloid precursor cells. These cells can accumulate in various tissues including skin, leading to tissue damage, and in some cases organ dysfunction. Herein, a report of a 1-year-old girl who presented with multiple lichenoid pinkish to purplish flat-topped papules, some of them were crusted and linear over the trunk mimicking lichen planus. The histopathologic and immunohistochemical staining confirmed the diagnosis of LCH. Awareness about this rare entity is important for early detection, timely intervention, and effective management.
朗格汉斯细胞组织细胞增多症（LCH）是一种未成熟髓样前体细胞的炎性克隆性增殖性肿瘤。这些细胞可积聚在包括皮肤在内的各种组织中，导致组织损伤，在某些情况下还会引起器官功能障碍。在此，报告一名1岁女童，其躯干出现多个苔藓样粉红色至紫色扁平丘疹，部分有结痂且呈线状，类似扁平苔藓。组织病理学和免疫组化染色确诊为LCH。认识这种罕见疾病对于早期发现、及时干预和有效管理至关重要。
