“周末战士”锻炼模式预防代谢相关脂肪性肝病和死亡率的效果与规律锻炼相当：全国队列研究
"Weekend Warrior" Exercise Pattern Protects Against MASLD and Mortality Comparable to Regular Exercise: National Cohort Study.
作者信息
Zelber-Sagi Shira, Paik James M, Ivancovsky-Wajcmen Dana, Henry Linda, Yilmaz Yusuf, Alqahtani Saleh A, El-Kassass Mohamed, Pekas Elizabeth J, Gerber Lynn H, Younossi Zobair M
机构信息
The Global NASH Council, Washington, DC, USA.
School of Public Health, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel.
出版信息
Liver Int. 2025 Aug;45(8):e70226. doi: 10.1111/liv.70226.
BACKGROUND AND AIMS
Metabolic dysfunction-associated steatotic liver disease (MASLD) guidelines recommend > 150 min per week of moderate-to-vigorous physical activity (MVPA). It is unclear if concentrating MVPA into 1-2 days per week ["weekend warrior" (WW) pattern] offers similar benefits to spreading activity throughout the week. We aimed to assess the association of WW activity pattern with MASLD prevalence, mortality, and atherosclerotic cardiovascular disease (ASCVD) risk among individuals with MASLD.
METHODS
Data from the National Health and Nutrition Examination Survey 2003-2006 were linked to mortality records through 2019. Using accelerometer measurements, participants were categorised as WW (> 150 min of MVPA with ≥ 50% of total MVPA accomplished over 1-2 days), active (> 150 min of MVPA, not meeting WW criteria) and inactive (≤ 150 min of MVPA per week). MASLD was defined as a United States Fatty Liver Index (US FLI) ≥ 30 with at least one cardiometabolic risk factor, excluding other liver diseases.
RESULTS
Among 2490 participants (mean age: 48.5 years; 47.4% male), both WW and active groups had lower odds of MASLD compared to the inactive group [WW; OR: 0.36 (95% CI 0.24-0.53); active; OR: 0.47 (0.36-0.62)], adjusting for sociodemographic variables. Among 859 MASLD, over 14.3 of years median follow-up, multivariable Cox regression showed lower all-cause mortality in the WW [HR: 0.35 (0.13-0.94)] and active [HR: 0.48 (0.24-0.98)] groups. Both WW [OR: 0.27 (0.09-0.75)] and active [OR: 0.39 (0.20-0.78)] groups had lower odds of high ASCVD risk.
CONCLUSIONS
WW physical activity patterns protect from MASLD and all-cause mortality comparable to regular exercise.
背景与目的
代谢功能障碍相关脂肪性肝病（MASLD）指南推荐每周进行超过150分钟的中等至剧烈身体活动（MVPA）。目前尚不清楚将MVPA集中在每周1 - 2天（“周末战士”模式）是否与将活动分散在一周内具有相似的益处。我们旨在评估“周末战士”活动模式与MASLD患病率、死亡率以及MASLD患者动脉粥样硬化性心血管疾病（ASCVD）风险之间的关联。
方法
将2003 - 2006年美国国家健康与营养检查调查的数据与截至2019年的死亡率记录相链接。利用加速度计测量结果，参与者被分为“周末战士”组（MVPA超过150分钟，且总MVPA的≥50%在1 - 2天内完成）、活跃组（MVPA超过150分钟，但不符合“周末战士”标准）和不活跃组（每周MVPA≤150分钟）。MASLD被定义为美国脂肪肝指数（US FLI）≥30且至少有一个心血管代谢风险因素，排除其他肝脏疾病。
结果
在2490名参与者（平均年龄：48.5岁；47.4%为男性）中，与不活跃组相比，“周末战士”组和活跃组患MASLD的几率均较低[“周末战士”组；比值比（OR）：0.36（95%置信区间0.24 - 0.53）；活跃组；OR：0.47（0.36 - 0.62）]，对社会人口统计学变量进行了调整。在859例MASLD患者中，经过中位数14.3年的随访，多变量Cox回归显示，“周末战士”组[风险比（HR）：0.35（0.13 - 0.94）]和活跃组[HR：0.48（0.24 - 0.98）]的全因死亡率较低。“周末战士”组[OR：0.27（0.09 - 0.75）]和活跃组[OR：0.39（0.20 - 0.78）]发生高ASCVD风险的几率均较低。
结论
“周末战士”身体活动模式与常规锻炼一样，可预防MASLD和全因死亡率。
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