Pathophysiological Traits in Pediatric Obstructive Sleep Apnea. Associations with Patient Characteristics and Responses to Therapy: A Secondary Analysis of CHAT Clinical Trial.

RATIONALE

In children with adenotonsillar hypertrophy, there is substantial variation in pediatric obstructive sleep apnea (pOSA) severity, which may be driven by differences in pathophysiological traits (endotypes) including pharyngeal collapsibility, dilator muscle compensation, arousal threshold, and chemoreflex loop gain. Objective (s): To determine if pathophysiological traits for pOSA vary with participant characteristics, correlate with pOSA severity, and change after adenotonsillectomy.

METHODS

Traits estimation, requiring adequate nasal pressure data quality, were performed during sleep (primary analysis in REM) from baseline polysomnography (N=1117; age 6.9±1.5 y; BMI-z 0.89±1.23; total AHI 5.1±9.1 events/hr; REM-AHI 11.0±20.1 events/hr) and post-intervention polysomnography (N=360; adenotonsillectomy or watchful waiting). Associations of each endotype (per SD) with AHI and with patient characteristics (race/ethnicity, age, sex, and BMI-z) were characterized using multivariable regression. The effects of adenotonsillectomy on AHI and endotypes were also examined.

RESULTS

The sample was comprised of 52% females and children from diverse racial and ethnic backgrounds and geographic sites. Higher REM-AHI was observed in Black (7.81±1.01, βadjusted±SEM, events/hour) and Asian (9.37±3.35) compared to White children; these differences were accompanied by greater collapsibility (0.30±0.09 per SD) in Black children and decreased compensation (-0.99±0.20) in Asian children. Notably, sex and BMI-z were not associated with any endotype. Higher REM-AHI was associated with greater collapsibility (13.64±1.73 events/hour/SD) and reduced compensation (-4.22±0.98) but not increased loop gain. Increased collapsibility and reduced compensation partially explained higher REM-AHI in Black as well as Asian and Indigenous children. Reduced AHI with adenotonsillectomy was accompanied by improved collapsibility in REM (∆=16.88±1.94%).

CONCLUSION

Increased collapsibility and reduced compensation contribute to higher REM AHI levels in children and may explain an elevated pOSA severity in REM in Black and Asian children.