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在接受单纯冠状动脉和主动脉瓣疾病心脏手术的心房颤动患者中进行同期手术消融:来自荷兰心脏注册研究的多中心研究

Concomitant Surgical Ablation in Atrial Fibrillation Patients Undergoing Cardiac Surgery for Isolated Coronary and Aortic Valve Disease: A Multicentre Study from The Netherlands Heart Registration.

作者信息

Bayón M Agustina, Scheurwater Miriam A, Verberkmoes Niels J, Mariani Massimo A, Roefs Maaike M, van der Palen Job, Dekker Lukas R C, Blaauw Yuri, van Brakel Thomas J

机构信息

Department of Cardiothoracic Surgery, University Medical Centre Groningen, Groningen 9713GZ, The Netherlands.

Department of Cardiothoracic Surgery, Catharina Ziekenhuis, Eindhoven 5623EJ, The Netherlands.

出版信息

Eur J Cardiothorac Surg. 2025 Aug 2;67(8). doi: 10.1093/ejcts/ezaf244.

Abstract

OBJECTIVES

Concomitant surgical ablation (CSA) is recommended for atrial fibrillation (AF) patients undergoing cardiac surgery; however, its effects in non-mitral valve surgeries, specifically coronary artery bypass grafting (CABG) and aortic valve replacement (AVR), are less studied. This study aims to analyse outcomes and trends of CSA performance in the Netherlands.

METHODS

This nationwide multicentre study utilized data from the Netherlands Heart Registration. AF patients undergoing CABG or AVR between 2013 and 2021 were included. Temporal trends in CSA performance were analysed and a multivariable regression model adjusted for confounders when comparing CSA and non-CSA.

RESULTS

A total of 3260 patients were included, of which 1081 underwent CSA. CSA patients showed longer cardiopulmonary bypass (CPB) (111 vs 80, mean difference between groups: 31 min [95% CI, 27-34, P < 0.001]) and aortic cross clamping (AoX) times (67 vs 52, mean difference: 15 min [95% CI, 13-17, P < 0.001]). After correcting for confounders, CSA patients presented mean CPB and AoX times of 18 (95% CI, 16-21, P < 0.001) and 8 (95% CI, 6-10, P < 0.001) min longer. The CSA group showed higher survival rates (92.5% vs 86.4%, P = 0.039) and greater improvements in mental quality of life (QoL) (P = 0.047). CSA performance during CABG and AVR has increased significantly, from 29.7% in 2018 to 44.4% in 2021.

CONCLUSIONS

CSA resulted in slightly longer CPB and AoX times but no significant differences in major complications. Regression analysis showed better survival rates and improved mental QoL for CSA. CSA performance in CABG and AVR has increased in the Netherlands.

摘要

目的

对于接受心脏手术的房颤(AF)患者,推荐同时进行手术消融(CSA);然而,其在非二尖瓣手术,特别是冠状动脉旁路移植术(CABG)和主动脉瓣置换术(AVR)中的效果研究较少。本研究旨在分析荷兰CSA手术的结果和趋势。

方法

这项全国性多中心研究使用了荷兰心脏注册的数据。纳入了2013年至2021年间接受CABG或AVR的房颤患者。分析了CSA手术的时间趋势,并在比较CSA和非CSA时使用多变量回归模型对混杂因素进行了调整。

结果

共纳入3260例患者,其中1081例接受了CSA。接受CSA的患者体外循环(CPB)时间更长(111分钟对80分钟,组间平均差异:31分钟[95%CI,27 - 34,P < 0.001]),主动脉阻断(AoX)时间更长(67分钟对52分钟,平均差异:15分钟[95%CI,13 - 17,P < 0.001])。校正混杂因素后,接受CSA的患者CPB和AoX平均时间分别长18分钟(95%CI,16 - 21,P < 0.001)和8分钟(95%CI,6 - 10,P < 0.001)。CSA组显示出更高的生存率(92.5%对86.4%,P = 0.039)和心理健康生活质量(QoL)的更大改善(P = 0.047)。CABG和AVR期间的CSA手术比例显著增加,从2018年的29.7%增至2021年的44.4%。

结论

CSA导致CPB和AoX时间略长,但主要并发症无显著差异。回归分析显示CSA组生存率更高,心理健康QoL有所改善。荷兰CABG和AVR中CSA手术的比例有所增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5596/12342894/029dc9b56162/ezaf244f4.jpg

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