Smirnov O A, Smirnova O N
Vopr Onkol. 1985;31(11):48-54.
A clinico-morphological analysis of the data available on cases of adeno-squamous carcinoma (72) and endometrial adenocarcinoma (102) pointed to a correlation between the decrease in the degree of cell differentiation in said neoplasms and the decline in the frequency of hyperestrimism and metabolic-endocrine disorders. As a result over 70% of well-differentiated cell tumors were referred to one pathogenetic pattern of endometrial carcinoma (after Bokhman) and more than 50% of poorly-differentiated cell tumors--to another one. These findings further support the rationale for distinguishing the well- and poorly-differentiated cell patterns of adeno-squamous carcinoma. They may be used in establishing individual prognosis as well as choosing optimal scheme of treatment.
对腺鳞癌(72例)和子宫内膜腺癌(102例)病例现有数据的临床形态学分析表明,上述肿瘤细胞分化程度的降低与雌激素过多症和代谢 - 内分泌紊乱频率的下降之间存在相关性。结果,超过70%的高分化细胞肿瘤属于子宫内膜癌的一种发病机制模式(根据博赫曼分类),而超过50%的低分化细胞肿瘤属于另一种模式。这些发现进一步支持了区分腺鳞癌高分化和低分化细胞模式的理论依据。它们可用于确定个体预后以及选择最佳治疗方案。