Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, UK.
School of Healthcare Sciences, Cardiff University, Cardiff, UK.
Rheumatology (Oxford). 2023 Aug 1;62(8):2716-2723. doi: 10.1093/rheumatology/keac676.
To identify and prioritize the top 10 research questions for PsA.
The British Psoriatic Arthritis Consortium (BritPACT) formed a Priority Setting Partnership (PSP) comprising of people living with PsA, carers and clinicians, supported by the James Lind Alliance (JLA). This PSP followed the established three-stage JLA process: first, an online survey of people living with PsA, carers and clinicians to identify PsA questions, asking, 'What do you think are the most important unanswered questions in psoriatic arthritis research?' The questions were checked against existing evidence to establish 'true uncertainties' and grouped as 'indicative questions' reflecting the overarching themes. Then a second online survey ranked the 'true uncertainties' by importance. Finally, a workshop including people living with PsA and clinician stakeholders finalized the top 10 research priorities.
The initial survey attracted 317 respondents (69% people living with PsA, 15% carers), with 988 questions. This generated 46 indicative questions. In the second survey, 422 respondents (78% people living with PsA, 4% carers) prioritized these. Eighteen questions were taken forward to the final online workshop. The top unanswered PsA research question was 'What is the best strategy for managing patients with psoriatic arthritis including non-drug and drug treatments?' Other top 10 priorities covered diagnosis, prognosis, outcome assessment, flares, comorbidities and other aspects of treatment (https://www.jla.nihr.ac.uk).
The top 10 priorities will guide PsA research and enable PsA researchers and those who fund research to know the most important questions for people living with PsA.
确定并确定最优先考虑的 10 个 PsA 研究问题。
英国银屑病关节炎联合会（BritPACT）成立了一个优先事项设定伙伴关系（PSP），由患有 PsA 的患者、护理人员和临床医生组成，由詹姆斯林德联盟（JLA）提供支持。该 PSP 遵循既定的 JLA 三阶段流程：首先，对患有 PsA 的患者、护理人员和临床医生进行在线调查，以确定 PsA 问题，询问“您认为银屑病关节炎研究中最重要的未解决问题是什么？”这些问题与现有证据进行了核对，以确定“真正的不确定性”，并将其分组为反映总体主题的“指示性问题”。然后，第二个在线调查对“真正的不确定性”进行了重要性排名。最后，包括患有 PsA 的患者和临床医生利益相关者的研讨会最终确定了前 10 项研究重点。
最初的调查吸引了 317 名受访者（69％为患有 PsA 的患者，15％为护理人员），收到了 988 个问题。这产生了 46 个指示性问题。在第二次调查中，422 名受访者（78％为患有 PsA 的患者，4％为护理人员）对这些问题进行了优先排序。有 18 个问题被带到了最终的在线研讨会。未解决的 PsA 研究的首要问题是“治疗银屑病关节炎患者（包括非药物和药物治疗）的最佳策略是什么？”其他前 10 项重点包括诊断，预后，结果评估，发作，合并症和其他治疗方面（https://www.jla.nihr.ac.uk）。
前 10 项重点将指导 PsA 研究，并使 PsA 研究人员和研究经费的提供者了解对患有 PsA 的患者最重要的问题。
