Ulmer Keely, Lyon-Scott Kristin, Wasson Ngoc, Haderlein Taona P, Bruegl Amanda
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Iowa Hospitals and Clinics Holden Comprehensive Cancer Center, Iowa City, USA.
OCHIN, Inc., PO Box 5426, Portland, OR, USA.
Cancer Causes Control. 2025 Jul 28. doi: 10.1007/s10552-025-02040-0.
Human papillomavirus (HPV) vaccination is recommended for individuals between 9 and 12 years of age to prevent six different cancers. Lower rates of vaccination exist among underserved populations. We evaluate rates of up-to-date (UTD) HPV vaccination within a nationwide network representing many medically underserved communities.
This study was conducted using OCHIN, a diverse national database of over 6 million publicly or underinsured patients seen at an OCHIN clinic from January 2015 to December 2023. HPV vaccination initiation and completion rates were the primary outcomes.
1,848,813 patients were included. HPV vaccination rates for all races and ethnic groups were below the Healthy People 2030 goal of 80.0%. Vaccination varied by race/ethnicity, with Hispanic individuals having the highest rates of UTD vaccination. There was no statistically significant difference between male and female genders for HPV vaccination. Odds of successful completion of the vaccine series were highest when series initiation occurred at ages 9-10 and among those with at least two clinical visits per year.
HPV vaccination completion rates remain below the national goal among all ages and racial/ethnic groups in this large, nationwide cohort though all rates increased throughout the study period for most groups. Hispanic race, younger age at initiation, and higher number of clinical visits had increased odds of HPV vaccination. Notably, the gap between males and females closed. Exploration in how these clinics is appealing to the Hispanic population; caregivers of younger children and the male population should be investigated.
建议9至12岁的个体接种人乳头瘤病毒（HPV）疫苗，以预防六种不同的癌症。在服务不足的人群中，疫苗接种率较低。我们评估了一个代表许多医疗服务不足社区的全国性网络中最新（UTD）HPV疫苗接种率。
本研究使用OCHIN进行，OCHIN是一个多样化的全国性数据库，包含2015年1月至2023年12月在OCHIN诊所就诊的600多万名公费或未参保患者。HPV疫苗接种起始率和完成率是主要结果。
纳入了1,848,813名患者。所有种族和族裔群体的HPV疫苗接种率均低于《健康人民2030》设定的80.0%的目标。疫苗接种情况因种族/族裔而异，西班牙裔个体的UTD疫苗接种率最高。HPV疫苗接种在男性和女性之间没有统计学上的显著差异。当在9至10岁开始接种疫苗系列且每年至少有两次临床就诊时，成功完成疫苗系列的几率最高。
在这个大型的全国性队列中，所有年龄组和种族/族裔群体的HPV疫苗接种完成率仍低于国家目标，尽管在研究期间大多数群体的接种率都有所提高。西班牙裔种族、接种起始年龄较小以及临床就诊次数较多，HPV疫苗接种的几率增加。值得注意的是，男性和女性之间的差距缩小了。应探究这些诊所如何吸引西班牙裔人群；还应调查年幼儿童和男性人群的护理人员情况。
