Cheng Ge, Tian Chi, Wang Waner, Zhou Yangyang, Wang Xiaoqing, Zhang Lei
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Henan University, Kaifeng, 475004, China.
Henan Provincial Engineering Center for Tumor Molecular Medicine, Kaifeng Key Laboratory of Cell Signal Transduction, Henan University, Kaifeng, 475004, China.
Cell Biosci. 2025 Jul 28;15(1):111. doi: 10.1186/s13578-025-01439-1.
SATB2 is an AT-rich DNA-binding protein with a highly restricted expression pattern, primarily found in the brain, digestive tract, bone, and immune system, making it a promising target for medical research and clinical applications. Dysregulation or mutations in SATB2 have been implicated in various conditions, including cancers, isolated cleft palate, and SATB2-associated syndrome (SAS). This review aims to provide a comprehensive summary of the structure, biological functions, and potential role of SATB2 in tumor development. SATB2 influences gene regulation through epigenetic modulation, impacting various biological activities, including cell differentiation and immune responses. Recent studies have increasingly recognized its roles in tumorigenesis, including its contributions to cancer progression and metastasis. Moreover, SATB2 shows promise as a diagnostic marker and therapeutic target in oncology and bone-related disorders. Understanding its precise mechanisms in these contexts can pave the way for future advancements in therapeutic strategies. This review highlights the current state of knowledge on the roles of SATB2 and discusses its structural characteristics, biological functions, and potential implications in tumor development.
SATB2是一种富含AT的DNA结合蛋白，其表达模式高度受限，主要存在于大脑、消化道、骨骼和免疫系统中，这使其成为医学研究和临床应用的一个有前景的靶点。SATB2的失调或突变与多种疾病有关，包括癌症、孤立性腭裂和SATB2相关综合征（SAS）。本综述旨在全面总结SATB2的结构、生物学功能及其在肿瘤发生中的潜在作用。SATB2通过表观遗传调控影响基因表达，进而影响包括细胞分化和免疫反应在内的各种生物学活性。最近的研究越来越认识到它在肿瘤发生中的作用，包括其对癌症进展和转移的影响。此外，SATB2在肿瘤学和骨相关疾病中有望作为诊断标志物和治疗靶点。了解其在这些情况下的精确机制可为未来治疗策略的进展铺平道路。本综述强调了目前关于SATB2作用的知识状态，并讨论了其结构特征、生物学功能及其在肿瘤发生中的潜在影响。
