Schmid B P, Hauser R E, Donatsch P
Xenobiotica. 1985 Aug-Sep;15(8-9):695-9. doi: 10.3109/00498258509047429.
Electron-microscopic examinations of rat embryonic yolk sacs treated in vitro with 1.5 X 10(-5) M cyproheptadine showed proliferation of the lysosomal structures; other organelles remained unaffected, and also overall yolk-sac growth and vascularization were comparable to non-treated samples. Radioactive measurements with 125I-labelled albumin showed that yolk sacs and embryos of the cyproheptadine-treated group incorporated less radioactivity than the controls. Embryos inside the yolk sacs, treated either for 24 or 48 h, were severely retarded in growth and differentiation (approximately 50% of the controls). It is suggested that the specific action of cyproheptadine on yolk-sac lysosomal structures, combined with reduced macromolecular transport, is the cause of inhibited embryonic development.
对体外经1.5×10⁻⁵ M赛庚啶处理的大鼠胚胎卵黄囊进行电子显微镜检查，结果显示溶酶体结构增殖；其他细胞器未受影响，而且卵黄囊的整体生长和血管形成与未处理样本相当。用¹²⁵I标记白蛋白进行放射性测量表明，赛庚啶处理组的卵黄囊和胚胎摄取的放射性比对照组少。在卵黄囊内处理24小时或48小时的胚胎，其生长和分化严重受阻（约为对照组的50%）。有人提出，赛庚啶对卵黄囊溶酶体结构的特定作用，加上大分子转运减少，是胚胎发育受抑制的原因。
