Nasal Injuries Related to Respiratory Support Interfaces in Preterm Infants: Neonatal Course and 12-Month Outcome.

: Respiratory support required by preterm infants involves contact between their immature skin and ventilation devices, which can lead to skin breakdown. : A prospective observational study including newborns with a nasal injury related to respiratory support, born at gestational age < 33 weeks, from May 2020 to January 2022, in the neonatal intensive care unit of Strasbourg. Injuries were recorded using a validated scale at inclusion and 3, 7 and 28 days. Sequelae were evaluated at discharge and 4, 9 and 12 months post-menstrual age. : In total, 64/276 newborns (23%) had a nasal injury. Most of the injuries were stage 2 (34/64, 53%) and stage 1 (25/64, 39%). The interface most frequently associated with injury was continuous positive airway pressure (53/64, 83%). Favorable evolution was associated with the injury site ( < 0.01) and the type of respiratory support needed when collecting at the 28th day ( = 0.04). At discharge, 34/58 infants (59%) had sequelae. The presence of a scar was associated with the maximum injury severity ( < 0.001) and total duration of respiratory support ( = 0.02). At 12 months, 31/47 infants (66%) had esthetic sequelae. : Nasal injuries related to respiratory support in preterm infants were frequent, and more than half of the injuries resulted in medium-term sequelae.