Harner Christopher, Gaffey Thomas A, Sullivan Shannon S, Witmans Manisha, DelRosso Lourdes M, Tablizo Mary Anne
College of Science, California State University, Turlock, CA 95382, USA.
Department of Psychology, University of Notre Dame, Notre Dame, IN 46556, USA.
Children (Basel). 2025 Jun 30;12(7):869. doi: 10.3390/children12070869.
Rett syndrome (RTT) is an X-linked neurodevelopmental disorder marked by neurological regression, autonomic dysfunction, seizures, and significant sleep and breathing abnormalities. About 80% of affected individuals, especially young children, experience sleep disturbances such as insomnia, sleep-disordered breathing, nocturnal vocalizations, bruxism, and seizures. Breathing irregularities during sleep-like apnea, alternating hyperventilation, and hypoventilation-are common, with both obstructive and central sleep apnea identified through polysomnography. This review focuses on the prevalent sleep disorders in children with Rett syndrome and highlights current recommendations for the management of sleep disorders.
雷特综合征（RTT）是一种X连锁神经发育障碍，其特征为神经功能退化、自主神经功能障碍、癫痫发作以及严重的睡眠和呼吸异常。约80%的受影响个体，尤其是幼儿，会出现睡眠障碍，如失眠、睡眠呼吸紊乱、夜间发声、磨牙症和癫痫发作。睡眠期间的呼吸不规则，如呼吸暂停、交替性过度通气和通气不足很常见，通过多导睡眠图可识别出阻塞性和中枢性睡眠呼吸暂停。本综述重点关注雷特综合征患儿中普遍存在的睡眠障碍，并强调了目前对睡眠障碍管理的建议。
