• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Integration of Adjunctive Therapy for Congenital Adrenal Hyperplasia.先天性肾上腺皮质增生症辅助治疗的整合
Children (Basel). 2025 Jul 8;12(7):898. doi: 10.3390/children12070898.
2
21-Hydroxylase-Deficient Congenital Adrenal Hyperplasia21-羟化酶缺乏所致先天性肾上腺皮质增生症
3
Impact of dual-release hydrocortisone on disease control and metabolism in congenital adrenal hyperplasia: a retrospective cohort study.双相释放氢化可的松对先天性肾上腺皮质增生症疾病控制和代谢的影响：一项回顾性队列研究
Endocrine. 2025 Jul 3. doi: 10.1007/s12020-025-04328-2.
4
Cytochrome P450 Oxidoreductase Deficiency细胞色素P450氧化还原酶缺乏症
5
Predicting Residual 21-Hydroxylase Enzymatic Activity in Pediatric and Adult Congenital Adrenal Hyperplasia Patients: Towards Individualized Therapy.预测儿童及成人先天性肾上腺皮质增生症患者的21-羟化酶残余酶活性：迈向个体化治疗
CPT Pharmacometrics Syst Pharmacol. 2025 Jul 27. doi: 10.1002/psp4.70086.
6
Non-classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency revisited: an update with a special focus on adolescent and adult women.非经典型先天性肾上腺皮质增生症（21-羟化酶缺乏症）再探：特别关注青少年和成年女性的更新内容。
Hum Reprod Update. 2017 Sep 1;23(5):580-599. doi: 10.1093/humupd/dmx014.
7
Phase 3 Trial of Crinecerfont in Adult Congenital Adrenal Hyperplasia.克立西芬治疗成人先天性肾上腺皮质增生的3期试验
N Engl J Med. 2024 Aug 8;391(6):504-514. doi: 10.1056/NEJMoa2404656. Epub 2024 Jun 1.
8
Expanded Steroid Profiling Identifies Novel Newborn Screening Markers for Congenital Adrenal Hyperplasia.扩展类固醇谱分析可识别先天性肾上腺皮质增生症的新型新生儿筛查标志物。
J Clin Endocrinol Metab. 2025 Jul 14. doi: 10.1210/clinem/dgaf402.
9
Diagnostic cut-offs of 17-hydroxyprogesterone by LC-MS/MS in children with non-classical congenital adrenal hyperplasia.采用液相色谱-串联质谱法测定非经典型先天性肾上腺皮质增生症患儿17-羟孕酮的诊断临界值。
J Endocrinol Invest. 2025 Apr 15. doi: 10.1007/s40618-025-02581-w.
10
Evaluation of Sleep Health in Children With Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency.21-羟化酶缺乏所致先天性肾上腺皮质增生症患儿睡眠健康状况评估
J Clin Endocrinol Metab. 2025 Jul 15;110(8):e2647-e2653. doi: 10.1210/clinem/dgae836.

本文引用的文献

1
PERSPECTIVE: Treatment with hydrocortisone modified-release capsules in children and adolescents with congenital adrenal hyperplasia: an expert opinion.观点：氢化可的松缓释胶囊治疗儿童及青少年先天性肾上腺皮质增生症：专家意见
Endocr Connect. 2025 Mar 26;14(5). doi: 10.1530/EC-24-0619. Print 2025 May 1.
2
Future Directions in the Management of Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency.21-羟化酶缺乏所致经典型先天性肾上腺皮质增生症的未来管理方向
J Clin Endocrinol Metab. 2025 Jan 21;110(Supplement_1):S74-S87. doi: 10.1210/clinem/dgae759.
3
Extended-release Hydrocortisone Formulations-Is There a Clinically Meaningful Benefit?长效氢化可的松制剂——是否具有临床显著益处？
J Clin Endocrinol Metab. 2025 Feb 18;110(3):e566-e573. doi: 10.1210/clinem/dgae822.
4
Comparison of modified-release hydrocortisone capsules versus prednisolone in the treatment of congenital adrenal hyperplasia.改良释放型氢化可的松胶囊与泼尼松龙治疗先天性肾上腺皮质增生症的比较。
Endocr Connect. 2024 Jul 18;13(8). doi: 10.1530/EC-24-0150. Print 2024 Aug 1.
5
Phase 3 Trial of Crinecerfont in Adult Congenital Adrenal Hyperplasia.克立西芬治疗成人先天性肾上腺皮质增生的3期试验
N Engl J Med. 2024 Aug 8;391(6):504-514. doi: 10.1056/NEJMoa2404656. Epub 2024 Jun 1.
6
Phase 3 Trial of Crinecerfont in Pediatric Congenital Adrenal Hyperplasia.三期临床试验中使用 Crinecerfont 治疗儿童先天性肾上腺皮质增生症。
N Engl J Med. 2024 Aug 8;391(6):493-503. doi: 10.1056/NEJMoa2404655. Epub 2024 Jun 2.
7
Gene therapy in pediatrics - Clinical studies and approved drugs (as of 2023).儿科基因治疗 - 临床研究与获批药物（截至 2023 年）。
Life Sci. 2024 Jul 1;348:122685. doi: 10.1016/j.lfs.2024.122685. Epub 2024 May 6.
8
AAV-delivered hepato-adrenal cooperativity in steroidogenesis: Implications for gene therapy for congenital adrenal hyperplasia.腺相关病毒介导的类固醇生成中肝-肾上腺协同作用：对先天性肾上腺皮质增生症基因治疗的意义。
Mol Ther Methods Clin Dev. 2024 Mar 12;32(2):101232. doi: 10.1016/j.omtm.2024.101232. eCollection 2024 Jun 13.
9
Congenital Adrenal Hyperplasia-Current Insights in Pathophysiology, Diagnostics, and Management.先天性肾上腺皮质增生症-病理生理学、诊断和治疗的最新见解。
Endocr Rev. 2022 Jan 12;43(1):91-159. doi: 10.1210/endrev/bnab016.
10
A Prospective Study of Children Aged 0-8 Years with CAH and Adrenal Insufficiency Treated with Hydrocortisone Granules.一项针对接受氢化可的松颗粒治疗的 0-8 岁先天性肾上腺皮质增生症和肾上腺皮质功能减退症患儿的前瞻性研究。
J Clin Endocrinol Metab. 2021 Mar 8;106(3):e1433-e1440. doi: 10.1210/clinem/dgaa626.

先天性肾上腺皮质增生症辅助治疗的整合

Integration of Adjunctive Therapy for Congenital Adrenal Hyperplasia.

作者信息

Speiser Phyllis W

机构信息

Department of Pediatrics, Donald and Barbara Zucker School of Medicine at Hofstra-Northwell, Hempstead, NY 11549, USA.

Cohen Children's Medical Center of New York, New Hyde Park, NY 11040, USA.

出版信息

Children (Basel). 2025 Jul 8;12(7):898. doi: 10.3390/children12070898.

DOI:10.3390/children12070898
PMID:40723091
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12293742/
Abstract

CAH represents a prototypical enzyme deficiency disorder, most commonly affecting steroid 21-hydroxylase, in which the critical adrenal pathway from cholesterol to cortisol is blocked [...].

摘要

先天性肾上腺皮质增生症是一种典型的酶缺乏症，最常见的是影响类固醇21-羟化酶，其中从胆固醇到皮质醇的关键肾上腺途径被阻断[...]。