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Toll样受体4 Asp299Gly单核苷酸多态性（rs4986790）通过改变Toll样受体4对脂多糖刺激的易感性来预防牙周炎性破坏。

TLR4 Asp299Gly SNP (rs4986790) Protects from Periodontal Inflammatory Destruction by Altering TLR4 Susceptibility to LPS Stimulation.

作者信息

Cavalla Franco, Biguetti Claudia C, Letra Ariadne, Silva Renato M, Vieira Alexandre R, Strauss Franz J, Garlet Gustavo P

机构信息

School of Dentistry, University Andres Bello, Santiago 7590924, Chile.

Conservative Dentistry Department, University of Chile, Santiago 8820808, Chile.

出版信息

Biology (Basel). 2025 Jul 21;14(7):894. doi: 10.3390/biology14070894.

DOI:10.3390/biology14070894
PMID:40723451
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12292776/
Abstract

Periodontitis is a multifactorial disease linked to host immune response and genetic predisposition. The TLR4 Asp299Gly single-nucleotide polymorphism (SNP, rs4986790) has been associated with altered responses to bacterial lipopolysaccharide (LPS) and may influence susceptibility to inflammatory diseases. Given the central role of TLR4 in innate immune recognition of periodontal pathogens, this study investigates the role of rs4986790 in modulating susceptibility to periodontal inflammatory destruction. A total of 1410 individuals from four populations were genotyped, with findings indicating a significant protective effect of the polymorphic allele. Functional assays demonstrated enhanced IL-8 secretion and increased sensitivity to CD14 inhibition in cells expressing the variant receptor. These results suggest that rs4986790 modifies the LPS response via TLR4, potentially offering protection against periodontal breakdown.

摘要

牙周炎是一种与宿主免疫反应和遗传易感性相关的多因素疾病。Toll样受体4（TLR4）的Asp299Gly单核苷酸多态性（SNP，rs4986790）与对细菌脂多糖（LPS）的反应改变有关，可能影响对炎症性疾病的易感性。鉴于TLR4在牙周病原体固有免疫识别中的核心作用，本研究调查了rs4986790在调节牙周炎症破坏易感性中的作用。对来自四个群体的1410名个体进行了基因分型，结果表明多态性等位基因具有显著的保护作用。功能测定表明，表达变异受体的细胞中白细胞介素-8分泌增强，对CD14抑制的敏感性增加。这些结果表明，rs4986790通过TLR4改变LPS反应，可能为预防牙周组织破坏提供保护。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e35/12292776/bfd5a0830377/biology-14-00894-g010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e35/12292776/46e536215f6e/biology-14-00894-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e35/12292776/d325caee28d1/biology-14-00894-g007.jpg
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本文引用的文献

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Endodontic Periapical Lesion: An Overview on the Etiology, Diagnosis and Current Treatment Modalities.牙髓根尖周病损：病因、诊断及当前治疗方法概述。
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TBX21-1993T/C (rs4794067) polymorphism is associated with increased risk of chronic periodontitis and increased T-bet expression in periodontal lesions, but does not significantly impact the IFN-g transcriptional level or the pattern of periodontophatic bacterial infection.TBX21 - 1993T/C（rs4794067）多态性与慢性牙周炎风险增加及牙周病变中T-bet表达增加相关，但对IFN-γ转录水平或牙周病原菌感染模式无显著影响。
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Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.单独使用甲硝唑或联合阿莫西林作为慢性牙周炎非手术治疗的辅助手段：一项为期 1 年的双盲、安慰剂对照、随机临床试验。
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