Ying Honglian, Zhao Hongli, Zhang Xiaqiu, Feng Haoyuan, Zhou Manjuan, Wu Zunqiu, Wu Ning
Chemistry and Biochemistry Laboratory, Guizhou Medical University, Guiyang 550025, China.
Biomolecules. 2025 Jun 30;15(7):947. doi: 10.3390/biom15070947.
Sepsis, a systemic inflammatory response syndrome triggered by infection, is characterized by acute onset, rapid progression, and high mortality. Ferroptosis, a form of programmed cell death induced by iron-dependent lipid peroxidation, is closely associated with the occurrence and development of various diseases. Microcystin-LR (MC-LR) can exacerbate sepsis by causing multi-organ damage via the ferroptosis pathway. Currently, the relationship between MC-LR, ferroptosis, and sepsis remains unclear. Understanding its pathogenesis and identifying potential therapeutic targets may reduce the mortality of sepsis patients and lead to clinical improvement. This article reviews the relationship among MC-LR, ferroptosis, and sepsis, focusing on the mechanism by which MC-LR exposure induces sepsis from the ferroptosis perspective, providing a theoretical basis for the prevention and treatment of MC-LR-exposure-induced sepsis in the population.
脓毒症是一种由感染引发的全身性炎症反应综合征，其特点是起病急、进展快、死亡率高。铁死亡是一种由铁依赖性脂质过氧化诱导的程序性细胞死亡形式，与多种疾病的发生和发展密切相关。微囊藻毒素-LR（MC-LR）可通过铁死亡途径导致多器官损伤，从而加重脓毒症。目前，MC-LR、铁死亡与脓毒症之间的关系尚不清楚。了解其发病机制并确定潜在的治疗靶点可能会降低脓毒症患者的死亡率并改善临床状况。本文综述了MC-LR、铁死亡与脓毒症之间的关系，重点从铁死亡角度探讨MC-LR暴露诱导脓毒症的机制，为人群中MC-LR暴露诱导的脓毒症的预防和治疗提供理论依据。
