Hirabayashi M, Okada S
Yakubutsu Seishin Kodo. 1985 Sep;5(3):231-41.
Effects of repeated administration of ephedrine (EPH) 40 and 80 mg/kg sc, and 20, 40, and 80 mg/kg ip on ambulatory activity in adult male mice of the dd strain were investigated. The drug was administered 5 times at intervals of 1 and 7 days. The ambulatory activity of each mouse was measured by a tilting-type round activity cage of 25 cm in diameter for 150-210 min after the drug administration. Repeated administration of EPH 80 mg/kg ip produced a marked augmentation in the sensitivity of the mouse, i.e. reverse tolerance, to the ambulation-increasing effect of the drug regardless of the administration intervals. However, repeated administration of 80 mg/kg sc and 40 mg/kg ip at intervals of 7 days caused a slight reverse tolerance, while 40 mg/kg sc at intervals of 7 days as well as 20 and 40 mg/kg ip at intervals of 1 day did not produce reverse tolerance. In contrast, a poorer development of reverse tolerance to the ambulation-increasing effect of EPH was observed when a mouse was confined in a glass jar of 5 cm in diameter to impede ambulation for 150-180 min after each administration. Mice showing reverse tolerance to EPH demonstrated an increased sensitivity to methamphetamine as compared with the saline-pretreated control mice. The present results suggest that the characteristics of reverse tolerance to ambulation-increasing effect of EPH are almost identical with those after methamphetamine and methylphenidate.
研究了腹腔注射麻黄碱（EPH）40和80mg/kg、皮下注射20、40和80mg/kg对成年dd品系雄性小鼠自主活动的影响。药物每隔1天和7天给药5次。给药后，使用直径25cm的倾斜式圆形活动笼，在150 - 210分钟内测量每只小鼠的自主活动。无论给药间隔如何，腹腔注射80mg/kg的EPH重复给药均使小鼠对药物增加活动的作用敏感性显著增强，即产生反向耐受。然而，每隔7天皮下注射80mg/kg和腹腔注射40mg/kg会产生轻微的反向耐受，而每隔7天皮下注射40mg/kg以及每隔1天腹腔注射20和40mg/kg则未产生反向耐受。相比之下，每次给药后将小鼠置于直径5cm的玻璃罐中限制活动150 - 180分钟时，观察到对EPH增加活动作用的反向耐受发展较差。与生理盐水预处理的对照小鼠相比，对EPH表现出反向耐受的小鼠对甲基苯丙胺的敏感性增加。目前的结果表明，对EPH增加活动作用的反向耐受特征与甲基苯丙胺和哌醋甲酯后的特征几乎相同。
