Kuribara H, Tadokoro S
Yakubutsu Seishin Kodo. 1985 Sep;5(3):271-7.
Combined effects of methamphetamine and morphine were investigated by means of ambulatory activity in mice and continuous avoidance response in rats. Single administration of methamphetamine (0.5-2 mg/kg sc) or morphine (2.5-10 mg/kg sc) increased the ambulatory activity in a dose-dependent manner. The ambulation-increasing effect of methamphetamine and morphine were synergistic throughout the combined doses tested. Methamphetamine (0.13 and 0.5 mg/kg sc) produced an increase in frequency of lever-pressing and a decrease in shock rate, showing facilitation of the avoidance response, in a dose-dependent manner. Morphine tended to facilitate the avoidance response at lower doses (1.3 and 2.5 mg/kg sc), whereas, at higher doses (5 and 10 mg/kg sc), it elicited decrease in the frequency of lever-pressing and increase in the shock rate, showing suppressing of the avoidance response. The avoidance-facilitating effect of methamphetamine was attenuated by higher doses of morphine. The present results suggest that combined administration of methamphetamine and morphine shows synergistic effect on ambulatory activity in mice, and synergistic and antagonistic effects on the avoidance response in rats depending on the doses combined.
通过小鼠的自主活动和大鼠的连续回避反应，研究了甲基苯丙胺和吗啡的联合作用。单独给予甲基苯丙胺（0.5 - 2毫克/千克，皮下注射）或吗啡（2.5 - 10毫克/千克，皮下注射）会以剂量依赖的方式增加自主活动。在整个测试的联合剂量范围内，甲基苯丙胺和吗啡的增加活动效果是协同的。甲基苯丙胺（0.13和0.5毫克/千克，皮下注射）会以剂量依赖的方式增加压杆频率并降低电击率，表明促进了回避反应。吗啡在较低剂量（1.3和2.5毫克/千克，皮下注射）时倾向于促进回避反应，而在较高剂量（5和10毫克/千克，皮下注射）时，它会引起压杆频率降低和电击率增加，表明抑制了回避反应。较高剂量的吗啡会减弱甲基苯丙胺的回避促进作用。目前的结果表明，甲基苯丙胺和吗啡联合给药对小鼠的自主活动显示出协同作用，对大鼠的回避反应根据联合剂量显示出协同和拮抗作用。
