Krajewska Maria, Witkowska-Sędek Ewelina
Department of Paediatrics and Endocrinology, Medical University of Warsaw, 02-091 Warsaw, Poland.
Life (Basel). 2025 Jul 20;15(7):1142. doi: 10.3390/life15071142.
Obesity-related low-grade inflammation is a significant factor responsible for the development of metabolic syndrome and chronic diseases, which can begin even in early childhood. Recently, there has been growing interest in the impact of vitamin D3 supplementation on inflammatory markers in overweight and obese individuals; however, findings remain inconsistent. Therefore, we aimed to conduct a systematic review to assess the effects of vitamin D3 supplementation on inflammatory markers in overweight and obese children and adolescents, focused exclusively on the analysis of randomized controlled trials (RCTs) identified by searching PubMed, EMBASE, and Cochrane Library. The results of this study were synthesized and reported following the PRISMA statement. A total of 294 citations were identified through electronic literature searches, of which two RCTs were finally included in our systematic review. We found that vitamin D3 supplementation did not affect the changes in C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), but led to a decrease in leptin levels. The small number of studies meeting the inclusion criteria for our systematic review limits the value of the presented results, but also indicates the need for in-depth research on this topic.
肥胖相关的低度炎症是导致代谢综合征和慢性疾病发生的一个重要因素，这种炎症甚至在儿童早期就可能开始。最近，人们越来越关注补充维生素D3对超重和肥胖个体炎症标志物的影响；然而，研究结果仍不一致。因此，我们旨在进行一项系统评价，以评估补充维生素D3对超重和肥胖儿童及青少年炎症标志物的影响，重点专门分析通过检索PubMed、EMBASE和Cochrane图书馆所确定的随机对照试验（RCT）。本研究结果按照PRISMA声明进行了综合和报告。通过电子文献检索共识别出294条引文，其中最终有两项RCT被纳入我们的系统评价。我们发现，补充维生素D3并未影响C反应蛋白（CRP）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）的变化，但导致瘦素水平下降。符合我们系统评价纳入标准的研究数量较少，这限制了所呈现结果的价值，但也表明有必要对该主题进行深入研究。
