Paraskeva Georgia, Michou Vasiliki, Koutlianos Nikolaos, Mameletzi Dimitra, Kouidi Evangelia
Sports Medicine Laboratory, School of Physical Education and Sport Science, Aristotle University, 57001 Thessaloniki, Greece.
Healthcare (Basel). 2025 Jul 17;13(14):1729. doi: 10.3390/healthcare13141729.
: Patients with chronic kidney disease (CKD) G5 treated with dialysis (G5D) often experience reduced physical activity levels and impaired health-related quality of life (HRQoL), which are associated with poor clinical outcomes. Understanding the factors that influence these outcomes is crucial for improving patient care. This study aimed to evaluate the levels of physical activity and HRQoL and investigate the influence of potential confounding factors on these outcomes in patients with CKD G5D. : One hundred and twenty-five patients with CKD G5D and 129 healthy controls completed a template with their general demographic and clinical information, followed by the short version of the International Physical Activity Questionnaire (IPAQ). Moreover, for patients with CKD G5D, the kidney disease-targeted version (KDQOL-SF36) was employed, whereas the healthy controls completed the standard SF-36. : A total of 59.2% of patients with CKD G5D demonstrated low physical activity levels, with a mean IPAQ score of 1163.38 MET-min/week, which was significantly lower than that of healthy controls ( = 0.002). Spearman's rho correlation analysis revealed significant associations between KDQOL subscales and variables including sex, age, Charlson Comorbidity Index (CCI), hemodialysis (HD) vintage, educational level, employment status, and IPAQ activity category (-values < 0.05). In the regression analyses, physical component summary (PCS) scores were significantly predicted by sex (β = 0.180, = 0.036), CCI (β = 0.239, = 0.045), and IPAQ total score (β = 0.316, < 0.001). IPAQ scores were predicted by age (β = -0.303, = 0.003), HD vintage (β = 0.275, = 0.012), and PCS (β = 0.343, = 0.002). : The findings demonstrated a statistically significant association between physical activity and HRQoL, underscoring the importance of promoting physical activity among patients with CKD G5D. Additionally, several underexplored sociodemographic and clinical confounders were identified as significant correlates of these outcome measures.
接受透析治疗的慢性肾脏病（CKD）G5期患者（G5D）常出现身体活动水平降低和健康相关生活质量（HRQoL）受损，这与不良临床结局相关。了解影响这些结局的因素对于改善患者护理至关重要。本研究旨在评估CKD G5D患者的身体活动水平和HRQoL，并调查潜在混杂因素对这些结局的影响。
125例CKD G5D患者和129名健康对照者填写了包含其一般人口统计学和临床信息的模板，随后完成了国际身体活动问卷简版（IPAQ）。此外，对于CKD G5D患者，采用了针对肾脏疾病的版本（KDQOL-SF36），而健康对照者完成了标准的SF-36。
共有59.2%的CKD G5D患者身体活动水平较低，IPAQ平均得分为1163.38代谢当量-分钟/周，显著低于健康对照者（P = 0.002）。Spearman等级相关分析显示，KDQOL各分量表与包括性别、年龄、Charlson合并症指数（CCI）、血液透析（HD）时间、教育水平、就业状况和IPAQ活动类别等变量之间存在显著关联（P值<0.05）。在回归分析中，身体成分总结（PCS）得分由性别（β = 0.180，P = 0.036）、CCI（β = 0.239，P = 0.045）和IPAQ总分（β = 0.316，P < 0.001）显著预测。IPAQ得分由年龄（β = -0.303，P = 0.003）、HD时间（β = 0.275，P = 0.012）和PCS（β = 0.343，P = 0.002）预测。
研究结果表明身体活动与HRQoL之间存在统计学上的显著关联，强调了在CKD G5D患者中促进身体活动的重要性。此外，还确定了几个未充分研究的社会人口统计学和临床混杂因素是这些结局指标的显著相关因素。
