Sinha Birandra K
Mechanistic Toxicology Branch, Division of Translational Toxicology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, Durham, NC 27709, USA.
Int J Mol Sci. 2025 Jul 11;26(14):6658. doi: 10.3390/ijms26146658.
Ferroptosis, a regulated form of cell death characterized by iron-dependent lipid peroxidation, has emerged as a pivotal mechanism in understanding the toxicological effects of various environmental pollutants. This short review delves into the intricate pathways of ferroptosis, its induction by diverse environmental toxicants, and the subsequent implications for human health. By elucidating and understanding pathways involved in environmental exposures and ferroptosis, we aim to shed light on potential therapeutic interventions and preventive strategies. Furthermore, identifications of biomarkers of ferroptosis will aid in monitoring ferroptosis-induced diseases/tissue damage, promoting the development of targeted therapies.
铁死亡是一种由铁依赖性脂质过氧化作用所介导的程序性细胞死亡形式，已成为理解各种环境污染物毒理效应的关键机制。本综述深入探讨了铁死亡的复杂途径、其被多种环境毒物诱导的过程以及对人类健康的后续影响。通过阐明和理解环境暴露与铁死亡相关的途径，我们旨在揭示潜在的治疗干预措施和预防策略。此外，鉴定铁死亡的生物标志物将有助于监测铁死亡诱导的疾病/组织损伤，推动靶向治疗的发展。
