Lee Gilyoung, Lee Geun-Shik
College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon 24341, Republic of Korea.
Int J Mol Sci. 2025 Jul 15;26(14):6768. doi: 10.3390/ijms26146768.
The aging process is associated with the emergence of low-grade, sterile inflammation, called inflammaging, which can accelerate aging-related diseases, such as neurodegenerative, cardiovascular, and musculoskeletal diseases. Recent studies have focused on the novel concept that inflammasomes represent a key innate immune pathway, mechanistically participating in aging-induced stress recognition. This review summarizes the advancements in inflammasome research related to aging. Particular attention is given to the close relationship between aging and inflammasomes and how these processes impact the health of the elderly. Inflammaging has various causes, such as metabolic disorders, changes in the gut microbiota, and immunosenescence. Hence, the connection between inflammasomes and these causes must be explored. This paper describes inflammasomes as a significant contributing factor among the mechanisms that make individuals susceptible to aging-related diseases and discusses the potential role of inflammasome regulation in effectively counteracting aging.
衰老过程与一种称为炎症衰老的低度无菌性炎症的出现有关，这种炎症会加速与衰老相关的疾病，如神经退行性疾病、心血管疾病和肌肉骨骼疾病。最近的研究集中在一个新的概念上，即炎性小体代表了一条关键的固有免疫途径，在机制上参与衰老诱导的应激识别。这篇综述总结了与衰老相关的炎性小体研究的进展。特别关注衰老与炎性小体之间的密切关系，以及这些过程如何影响老年人的健康。炎症衰老有多种原因，如代谢紊乱、肠道微生物群变化和免疫衰老。因此，必须探索炎性小体与这些原因之间的联系。本文将炎性小体描述为使个体易患与衰老相关疾病的机制中的一个重要促成因素，并讨论了炎性小体调节在有效对抗衰老方面的潜在作用。
