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[左旋多巴治疗儿童变形性肌张力障碍及婴儿脑性瘫痪中的张力障碍性运动亢进的经验]

[Experience with L-DOPA treatment of children with dystonia musculorum deformans and dystonic hyperkineses in infantile cerebral palsy].

作者信息

Bondarenko E S, Malyshev Iu I

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1985;85(10):1471-5.

PMID:4072505
Abstract

Nineteen children with dystonia musculorum deformans and dystonic hyperkineses were treated by L-DOPA. A mild positive effect was obtained in 6 children, a considerable positive effect in 9 children. A more marked positive effect was obtained in children with dystonia musculorum deformans. The results indicate the efficiency of L-DOPA in the treatment of dystonia musculorum deformans and dystonic hyperkineses against the residual organic background. The advisability of 2-3 month long courses of therapy with L-DOPA 2-3 times a year is discussed. Some patients may need a continuous therapy with maintenance doses of the drug.

摘要

19名患有变形性肌张力障碍和张力障碍性运动亢进的儿童接受了左旋多巴治疗。6名儿童获得了轻度积极效果,9名儿童获得了显著积极效果。在患有变形性肌张力障碍的儿童中获得了更明显的积极效果。结果表明,左旋多巴在治疗变形性肌张力障碍和张力障碍性运动亢进方面对残留器质性背景有效。讨论了每年2 - 3次、为期2 - 3个月的左旋多巴治疗疗程的合理性。一些患者可能需要持续服用维持剂量的药物进行治疗。

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