Yuan Ye, Guan Zhenhua, Zhang Xue-Jie, Yao Nanyu, Yuan Wenling, Zhang Yonghui, Ye Ying, Xiang Zheng
State Key Laboratory of Chemical Oncogenomics, Shenzhen Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, P. R. China.
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P. R. China.
Beilstein J Org Chem. 2025 Jul 21;21:1489-1495. doi: 10.3762/bjoc.21.111. eCollection 2025.
A novel strategy for the synthesis of fusicoccane diterpenoids is reported. By harnessing the biosynthetic pathways of brassicicenes and fusicoccins, cotylenol was produced in an engineered strain. We further achieved the concise synthesis of three fusicoccane diterpenoids, including alterbrassicicene E and brassicicenes A and R in 4 or 5 chemical steps from brassicicene I. This strategy lays the foundation for the preparation of fusicoccane diterpenoids and their analogues for biological studies.
报道了一种合成壳梭孢烷二萜类化合物的新策略。通过利用油菜素和壳梭孢菌素的生物合成途径，在工程菌株中产生了棉子醇。我们进一步实现了从油菜素I经4或5步化学反应简洁合成三种壳梭孢烷二萜类化合物，包括变油菜素E、油菜素A和R。该策略为制备用于生物学研究的壳梭孢烷二萜类化合物及其类似物奠定了基础。
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