Sinha Sounak, Yasmin Shamima, Patra Manas, Sinha Nirmalya, Ahmed Ashfaque
Undergraduate MBBS student, Institute of Post-Graduate Medical Eduaction and Research, Kolkata, West Bengal, India.
Department of Community Medicine, Calcutta Medical College, Kolkata, West Bengal, India.
J Family Med Prim Care. 2025 Jun;14(6):2346-2350. doi: 10.4103/jfmpc.jfmpc_1702_24. Epub 2025 Jun 30.
Nonalcoholic fatty liver disease (NAFLD), a wide spectrum of liver disease ranged from mild steatosis to advance fibrosis, cirrhosis, liver failure and hepato-cellular carcinoma, showed rising trend globally. Prevalent evidences support coexistence between NAFDL and metabolic syndrome.
The present study aims to demonstrate the sociodemographic and clinical profile of nonalcoholic fatty liver diseases and its association with metabolic syndrome if any.
The present cross-sectional study was conducted among the 120 patients diagnosed as NAFLD by ultrasonography as well as similar numbers of matching controls in a tertiary care teaching hospital of eastern part of India. Relevant anthropometric measurements, laboratory investigations and imaging techniques were performed. Metabolic syndrome was classified by the 'International Diabetes Federation, 2005' criteria. Pearson's chi-square test used for measures of association, and < 0.05 was taken as level of significance.
The overall prevalence of metabolic syndrome among the NAFLD study population was 64.2%. Significant positive association found with several cardiometabolic components such as increased body mass index, central obesity, hypertension, fasting blood sugar, dyslipidaemia and NAFLD.
The prevalence of metabolic syndrome among NAFLD patients was found quite high and significant positive association found between metabolic syndrome and its components and NAFLD. Early detection of NAFLD might play a vital role in preventive cardiology.
非酒精性脂肪性肝病(NAFLD)是一种范围广泛的肝脏疾病,从轻度脂肪变性到进展性纤维化、肝硬化、肝衰竭和肝细胞癌,在全球呈上升趋势。现有证据支持NAFLD与代谢综合征并存。
本研究旨在阐明非酒精性脂肪性肝病的社会人口统计学和临床特征及其与代谢综合征(若有)的关联。
本横断面研究在印度东部一家三级护理教学医院中,对120例经超声诊断为NAFLD的患者以及数量相当的匹配对照进行。进行了相关人体测量、实验室检查和影像学检查。代谢综合征根据“国际糖尿病联盟,2005”标准进行分类。采用Pearson卡方检验进行关联性分析,以P<0.05作为显著性水平。
NAFLD研究人群中代谢综合征的总体患病率为64.2%。发现与多个心脏代谢成分存在显著正相关,如体重指数增加、中心性肥胖、高血压、空腹血糖、血脂异常和NAFLD。
NAFLD患者中代谢综合征的患病率相当高,且代谢综合征及其组分与NAFLD之间存在显著正相关。NAFLD的早期检测可能在预防心脏病学中发挥至关重要的作用。