呼吸道合胞病毒疫苗诱导的血栓性微血管病

Respiratory Syncytial Virus Vaccine Induced Thrombotic Microangiopathy.

作者信息

Seby Robert, McCormick Benjamin J, Wolf Emily, Kuhlman Justin, Jhawar Nikita, Oman Sven Peter, Kase Adam M, Christenson Chancey, Shaikh Marwan

机构信息

Department of Internal Medicine, Mayo Clinic, Jacksonville, FL, USA.

Department of Hematology/Oncology, Mayo Clinic, Jacksonville, FL, USA.

出版信息

J Blood Med. 2025 Jul 22;16:331-335. doi: 10.2147/JBM.S478230. eCollection 2025.

DOI:10.2147/JBM.S478230

PMID:40727950

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12301135/

Abstract

Microangiopathic hemolytic anemia with associated multiorgan failure is a medical emergency. The differential diagnosis for microangiopathic hemolytic anemia is broad and requires a systematic, focused approach at ruling out serious causes. However, with the rise of new vaccines and sporadic reports of vaccine-induced microangiopathic hemolytic anemia, it is essential for providers to include vaccines as a potential cause on their differential diagnosis. Here, we report the first case of respiratory syncytial virus vaccine-induced microangiopathic hemolytic anemia, anuric renal failure, and metabolic encephalopathy in the world.

摘要

伴有多器官功能衰竭的微血管病性溶血性贫血是一种医疗急症。微血管病性溶血性贫血的鉴别诊断范围广泛，需要采用系统、有针对性的方法来排除严重病因。然而，随着新疫苗的出现以及疫苗诱导的微血管病性溶血性贫血的零星报道，临床医生在鉴别诊断时将疫苗作为潜在病因纳入考虑至关重要。在此，我们报告了世界上首例呼吸道合胞病毒疫苗诱导的微血管病性溶血性贫血、无尿性肾衰竭和代谢性脑病病例。