Bücher T, Dünnwald M, Linke I M, Rabes H M
Adv Enzyme Regul. 1985;23:169-78. doi: 10.1016/0065-2571(85)90046-9.
Experimental conditions are discussed that are necessary for a useful application of genetically marked laboratory animals to distinguish between clonal and nonclonal origin of induced tumors: quantitative discrimination of biochemical markers, definition of the "patch" sizes, evaluation of possible admixture of "contaminating" cells and the approach to congenicity of parental animal strains.
生化标记的定量鉴别、“斑块”大小的定义、“污染”细胞可能的混合评估以及亲本动物品系同基因性的方法。
