Michalakis Polychronis, Vasilaki Dimitra, Abdallah Ali Jihad, Asikis Charilaos, Niakou Athina, Stratos Athanasios, Tsouknidas Alexandros, Johnstone Elaine, Michalakis Konstantinos
Faculty of Health Sciences, European University of Cyprus, Nicosia 2404, Cyprus.
Center for Multiscale and Translational Mechanobiology, School of Dental Medicine, Boston University, Boston, MA 02118, USA.
Curr Issues Mol Biol. 2025 Jun 20;47(7):477. doi: 10.3390/cimb47070477.
During cancer initiation, normal cells acquire mutations disrupting standard cellular processes, activating oncogenes and inactivating tumor suppressor genes, acquiring the well-described hallmarks of cancer on the path to malignancy. This process is influenced by a combination of physiological and metabolic pathways, as well as environmental cues, and leads to abnormal cell cycle, increased cell motility, and invasive characteristics. Cancer cell organelles also present some distinct differences from those of normal cells. Cancer progression requires certain tumorigenic biochemical pathways to be activated. However, mechanical cues are also important, as they have an effect on cell differentiation and fate. A continuous biochemical-biomechanical interaction exists, which affects the mechanical properties of the cells, as well as their behavior. This review aims to focus on the mathematical relationships governing cancer mechanobiology and examine how the altered mechanical properties of a cancer cell may affect malignant progression.
在癌症起始阶段，正常细胞获得突变，破坏标准细胞过程，激活癌基因并使肿瘤抑制基因失活，在迈向恶性肿瘤的过程中获得了已充分描述的癌症特征。这一过程受生理和代谢途径以及环境线索的综合影响，导致细胞周期异常、细胞运动性增加和侵袭性特征。癌细胞的细胞器也与正常细胞的细胞器存在一些明显差异。癌症进展需要某些致瘤生化途径被激活。然而，机械信号也很重要，因为它们会影响细胞分化和命运。存在持续的生化 - 生物力学相互作用，这会影响细胞的力学性质及其行为。本综述旨在聚焦于支配癌症机械生物学的数学关系，并研究癌细胞改变的力学性质如何影响恶性进展。
