Bulu Aykut, Onalan Erhan, Yakar Burkay, Bulu Gulay, Yıldırım Senanur Onalan, Gursu Mehmet Ferit, Kaplankaya Ugur, Donder Emir, Kaymaz Tugce
Department of Internal Medicine, Fethi Sekin City Hospital, 23280 Elazig, Turkey.
Department of Internal Medicine, Firat University, 23119 Elazig, Turkey.
Medicina (Kaunas). 2025 Jul 10;61(7):1247. doi: 10.3390/medicina61071247.
: This study aimed to investigate the relationship between Maresin-1 (MaR1), Chitinase-3-like protein 1 (CHI3L1), and inflammatory as well as hematological markers in patients with type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN). : This cross-sectional study included 90 participants divided into three groups: healthy controls ( = 30), patients with T2DM ( = 30), and patients with diabetic nephropathy ( = 30). The serum levels of MaR1 and CHI3L1 were measured using ELISA. Biochemical and hematological parameters were also assessed. Statistical comparisons were conducted using non-parametric tests, and correlations were analyzed via Spearman correlation. : Serum MaR1 levels were significantly higher in DN patients compared to both T2DM patients and controls ( < 0.01), while CHI3L1 levels were significantly lower in the DN group compared to controls ( = 0.007). MaR1 showed a positive correlation with CRP, BUN, and creatinine, and a negative correlation with GFR. CHI3L1 levels were positively correlated with GFR and negatively with BUN. Inflammatory markers such as CRP were elevated in the diabetic groups, while no significant differences were found in NLR values. : Elevated MaR1 levels in DN patients and their correlation with renal dysfunction markers suggest that MaR1 may serve as a potential prognostic biomarker in diabetic nephropathy. The unexpected decrease in CHI3L1 levels in DN patients indicates the need for further research to clarify their role. These findings indicated that MaR1 and CHI3L1 should be further investigated in future studies as indicators for the early detection and monitoring of diabetic complications.
本研究旨在探讨maresin-1（MaR1）、几丁质酶-3样蛋白1（CHI3L1）与2型糖尿病（T2DM）及糖尿病肾病（DN）患者炎症和血液学指标之间的关系。本横断面研究纳入90名参与者，分为三组：健康对照组（n = 30）、T2DM患者（n = 30）和糖尿病肾病患者（n = 30）。采用酶联免疫吸附测定法（ELISA）检测MaR1和CHI3L1的血清水平。还评估了生化和血液学参数。使用非参数检验进行统计学比较，并通过Spearman相关性分析相关性。与T2DM患者和对照组相比，DN患者的血清MaR1水平显著更高（P < 0.01），而与对照组相比，DN组的CHI3L1水平显著更低（P = 0.007）。MaR1与C反应蛋白（CRP）、尿素氮（BUN）和肌酐呈正相关，与肾小球滤过率（GFR）呈负相关。CHI3L1水平与GFR呈正相关，与BUN呈负相关。糖尿病组中CRP等炎症标志物升高，而中性粒细胞与淋巴细胞比值（NLR）值无显著差异。DN患者中MaR1水平升高及其与肾功能障碍标志物的相关性表明，MaR1可能作为糖尿病肾病的潜在预后生物标志物。DN患者中CHI3L1水平意外降低表明需要进一步研究以阐明其作用。这些发现表明，在未来的研究中应进一步研究MaR1和CHI3L1作为糖尿病并发症早期检测和监测指标的情况。
