Uslu Emine Yıldırım, Uslu Muhammed Fuad, Yıldız Sevler, Tabara Muhammed Fatih
Department of Physical Medicine and Rehabilitation, Elazığ Fethi Sekin City Hospital, 23280 Elazig, Turkey.
Department of Internal Medicine, Elazığ Fethi Sekin City Hospital, 23280 Elazig, Turkey.
Medicina (Kaunas). 2025 Jul 10;61(7):1248. doi: 10.3390/medicina61071248.
: This study aimed to evaluate the diagnostic value of oxidative stress parameters in fibromyalgia syndrome (FMS) and to investigate their potential associations with disease severity, functional impairment, anxiety, and depression. : The study included 84 participants, consisting of 42 women diagnosed with fibromyalgia (FM) and 42 healthy female controls. Serum levels of total antioxidant status (TAS), total oxidant status (TOS), and malondialdehyde (MDA) were measured in all participants, and the oxidative stress index (OSI) was calculated. Additionally, the Fibromyalgia Impact Questionnaire (FIQ), Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI) were administered to assess mental health and functional status. : The levels of TOS, TAS, MDA, and the OSI were significantly higher in the fibromyalgia group compared to the control group ( < 0.001). The relationship between TAS, TOS, MDA, and OSI levels and BDI, BAI, and FIQ scale scores was investigated in the case group, but no significant associations were identified between oxidative stress markers and psychological or functional scores. When all participants were analyzed as a single group, significant correlations were found between TAS, TOS, MDA, and OSI levels and several biochemical parameters, including CRP, AST, free T4, HbA1c, ferritin, and folic acid. : Our study adds to the growing body of evidence indicating elevated oxidative stress in female patients with fibromyalgia syndrome (FMS) and suggests that TAS, TOS, MDA, and OSI may serve as potential biomarkers for its diagnosis.
本研究旨在评估氧化应激参数在纤维肌痛综合征（FMS）中的诊断价值，并探讨它们与疾病严重程度、功能损害、焦虑和抑郁之间的潜在关联。本研究纳入了84名参与者，包括42名被诊断为纤维肌痛（FM）的女性和42名健康女性对照。测量了所有参与者的血清总抗氧化状态（TAS）、总氧化状态（TOS）和丙二醛（MDA）水平，并计算了氧化应激指数（OSI）。此外，使用纤维肌痛影响问卷（FIQ）、贝克抑郁量表（BDI）和贝克焦虑量表（BAI）来评估心理健康和功能状态。与对照组相比，纤维肌痛组的TOS、TAS、MDA和OSI水平显著更高（<0.001）。在病例组中研究了TAS、TOS、MDA和OSI水平与BDI、BAI和FIQ量表评分之间的关系，但未发现氧化应激标志物与心理或功能评分之间存在显著关联。当将所有参与者作为一个单一组进行分析时，发现TAS、TOS、MDA和OSI水平与包括CRP、AST、游离T4、糖化血红蛋白、铁蛋白和叶酸在内的几个生化参数之间存在显著相关性。我们的研究增加了越来越多的证据，表明纤维肌痛综合征（FMS）女性患者的氧化应激升高，并表明TAS、TOS、MDA和OSI可能作为其诊断的潜在生物标志物。
