Bhattacharjee Rounak, Deb Tanushree, Roy Prosenjit, Bhattacharjee Prithwiraj, Rosas Israel Maldonado, Roychoudhury Shubhadeep
Department of Medicine, Lumding Civil Hospital, Lumding 782447, India.
Department of Medicine, Pragjyotishpur Medical College and Hospital, Guwahati 781009, India.
Medicina (Kaunas). 2025 Jul 11;61(7):1260. doi: 10.3390/medicina61071260.
: Chronic obstructive pulmonary disease (COPD) significantly impacts morbidity and mortality, often due to cardiovascular comorbidities that are frequently overlooked. This study examines the prevalence of left ventricular dysfunction in COPD patients and its association with disease severity, hypoxemia, and exacerbation frequency. : COPD patients ( = 114) were evaluated using spirometry and transthoracic echocardiography. Statistical analysis utilized Student's -test, chi-square test, and multivariable logistic regression with 1000 bootstrapping iterations, considering < 0.05 as significant differences. : Most patients were classified as Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage III (40.4%) and stage IV (44.7%). Diastolic dysfunction was present in 67.5% of the patients (Grade 1: 53.5%, Grade 2: 13. 2%, Grade 3: 0.0.9%), while 18.4% exhibited systolic dysfunction (LVEF < 50%). The prevalence of diastolic dysfunction increased significantly, from 41.2% in GOLD stage II to 92. 2% in GOLD stage IV ( < 0.001). Independent predictors of diastolic dysfunction included GOLD stage IV (Odds Ratio [OR]: 5.39, 95% Confidence Interval [CI]: 1. 42-23.35, < 0.001), older age (OR: 1.02 per year, 95% CI: 1.01-1.04, = 0.025), and a history of frequent exacerbations (OR: 1.09 per event, 95% CI: 1.01-1.17, = 0.039). Systolic dysfunction correlated significantly with GOLD stage IV (OR: 1.83, = 0.014), oxygen saturation below 88% (OR: 3.12, = 0.036), and having three or more exacerbations (OR: 4.18, = 0.008). : This study reveals a high prevalence of left ventricular dysfunction in COPD patients, linked to disease severity, hypoxemia, and frequent exacerbations. It supports incorporating complementary echocardiographic assessments in managing advanced COPD, especially for those with frequent exacerbations or oxygen desaturation.
慢性阻塞性肺疾病（COPD）对发病率和死亡率有显著影响，这通常是由于常常被忽视的心血管合并症所致。本研究调查了COPD患者左心室功能障碍的患病率及其与疾病严重程度、低氧血症和急性加重频率的关联。：对114例COPD患者进行了肺量计检查和经胸超声心动图检查。统计分析采用了Student's t检验、卡方检验以及带有1000次自抽样迭代的多变量逻辑回归分析，将P<0.05视为显著差异。：大多数患者被归类为慢性阻塞性肺疾病全球倡议组织（GOLD）III期（40.4%）和IV期（44.7%）。67.5%的患者存在舒张功能障碍（1级：53.5%，2级：13.2%，3级：0.9%），而18.4%的患者表现出收缩功能障碍（左心室射血分数<50%）。舒张功能障碍的患病率显著增加，从GOLD II期的41.2%增至GOLD IV期的92.2%（P<0.001）。舒张功能障碍的独立预测因素包括GOLD IV期（比值比[OR]：5.39，95%置信区间[CI]：1.42 - 23.35，P<0.001）、年龄较大（每年OR：1.02，95%CI：1.01 - 1.04，P = 0.025）以及频繁急性加重病史（每次事件OR：1.09，95%CI：1.01 - 1.17，P = 0.039）。收缩功能障碍与GOLD IV期（OR：1.83，P = 0.014）、氧饱和度低于88%（OR：3.12，P = 0.036）以及有三次或更多次急性加重（OR：4.
