Sabbatucci Michela, Clerici Pierangelo, Creti Roberta
Unit 2, Directorate General of Health Emergencies, Department of Prevention, Research and Health Emergencies, Ministry of Health, 00144 Rome, Italy.
Italian Clinical Microbiologists Association (AMCLI), 20159 Milano, Italy.
Microorganisms. 2025 Jun 20;13(7):1438. doi: 10.3390/microorganisms13071438.
Invasive neonatal GBS infections constitute a major cause of sepsis and meningitis in Western countries. Vaginal/rectal GBS colonization during pregnancy is the main risk factor for the development of early-onset infections (GBS-EOD) in newborn by vertical transmission at birth, in addition to prematurity and stillbirth. In Italy, intrapartum antibiotic prophylaxis (IAP) to prevent GBS-EOD is offered to pregnant women who tested as GBS-positive in late pregnancy. Passive surveillance in Italy showed that a non-negligible number of GBS-EOD cases (about 50%) occurred from GBS-negative pregnant women. This finding prompted the launch of a national online survey from 15 December 2022 to 12 February 2023 to investigate the microbiological procedures followed for GBS identification in Italian public and private microbiology laboratories, the prevalence of maternal GBS colonization, and the incidence of GBS-EOD cases. The survey results demonstrated that national guidelines for the prevention of EOD-GBS cases as well as harmonization of microbiological methodologies for GBS identification in the antenatal screening are needed.
在西方国家，新生儿侵袭性B族链球菌（GBS）感染是败血症和脑膜炎的主要病因。孕期阴道/直肠GBS定植是新生儿早发型感染（GBS-EOD）的主要危险因素，通过分娩时的垂直传播导致感染，此外还有早产和死产。在意大利，对于妊娠晚期GBS检测呈阳性的孕妇，会提供产时抗生素预防（IAP）以预防GBS-EOD。意大利的被动监测显示，相当数量的GBS-EOD病例（约50%）发生在GBS阴性的孕妇中。这一发现促使在2022年12月15日至2023年2月12日开展了一项全国在线调查，以调查意大利公共和私人微生物实验室中GBS鉴定所采用的微生物学程序、孕产妇GBS定植的患病率以及GBS-EOD病例的发生率。调查结果表明，需要制定预防EOD-GBS病例的国家指南以及统一产前筛查中GBS鉴定的微生物学方法。
