Brantlov Steven, Ward Leigh C, Isidor Søren, Hvas Christian Lodberg, Rud Charlotte Lock, Jødal Lars
Department of Procurement & Clinical Engineering, Central Denmark Region, 8200 Aarhus, Denmark.
School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane 4072, Australia.
Sensors (Basel). 2025 Jul 12;25(14):4362. doi: 10.3390/s25144362.
Cell membrane capacitance () is a potential biomarker that reflects the structural and functional integrity of cell membranes. It is essential for physiological processes such as signal transduction, ion transport, and cellular homeostasis. In clinical practice, can be determined using bioimpedance spectroscopy (BIS), a non-invasive technique for analysing the intrinsic electrical properties of biological tissues across a range of frequencies. may be relevant in various clinical fields, where high capacitance is associated with healthy and intact membranes, while low capacitance indicates cellular damage or disease. Despite its promise as a prognostic indicator, several knowledge gaps limit the broader clinical application of . These include variability in measurement techniques (e.g., electrode placement, frequency selection), the lack of standardised measurement protocols, uncertainty on how is related to pathology, and the relatively low amount of research. By addressing these gaps, may become a valuable tool for examining cellular health, early disease detection, and evaluating treatment efficacy in clinical practice. This review explores the fundamental principles of measured with the BIS technique, its mathematical basis and relationship to the biophysical Cole model, and its potential clinical applications. It identifies current gaps in our knowledge and outlines future research directions to enhance the understanding and use of . For example, has shown promise in identifying membrane degradation in sepsis, predicting malnutrition in anorexia nervosa, and as a prognostic factor in cancer.
细胞膜电容（）是一种潜在的生物标志物，反映细胞膜的结构和功能完整性。它对于信号转导、离子运输和细胞稳态等生理过程至关重要。在临床实践中，可使用生物阻抗谱（BIS）来测定，BIS是一种用于分析生物组织在一系列频率范围内固有电学特性的非侵入性技术。在各种临床领域中可能都具有相关性，其中高电容与健康且完整的膜相关，而低电容则表明细胞损伤或疾病。尽管其作为一种预后指标具有前景，但一些知识空白限制了其在更广泛临床中的应用。这些包括测量技术的变异性（例如电极放置、频率选择）、缺乏标准化的测量方案、关于与病理学如何相关的不确定性以及相对较少的相关研究。通过解决这些空白，可能会成为临床实践中检查细胞健康、早期疾病检测和评估治疗效果的有价值工具。本综述探讨了用BIS技术测量的基本原理、其数学基础以及与生物物理科尔模型的关系，及其潜在的临床应用。它确定了我们目前知识中的空白，并概述了未来的研究方向，以加强对的理解和应用。例如，在识别脓毒症中的膜降解、预测神经性厌食症中的营养不良以及作为癌症的预后因素方面已显示出前景。
