Dauletbakov Anuar, Belyankova Yelizaveta, Assylbekova Saniya, Zolotareva Darya, Bayazit Sarah, Baktybayeva Layilya, Kemelbekov Ulan, Yu Valentina, Ibragimova Nailya, Zazybin Alexey
School of Chemical Engineering, Kazakh-British Technical University, 59 Tole bi Str., Almaty 050000, Kazakhstan.
Department of Biophysics, Biomedicine and Neuroscience, Al-Farabi Kazakh National University, al-Farabi Ave, 71, Almaty 050040, Kazakhstan.
Molecules. 2025 Jul 15;30(14):2967. doi: 10.3390/molecules30142967.
This study presents the synthesis and antidiabetic and hematopoietic activity of ionic compounds based on 2-(diphenylmethoxy)-,-dimethylethanamine (diphenhydramine). Synthesis is carried out under ultrasonic (US) and microwave (MW) irradiation as well as using a conventional method (thermal activation). The synthesized ionic compounds have been tested for antidiabetic effect according to the inhibitory action against α-glucosidase and α-amylase (in vitro). All the synthesized derivatives of diphenhydramine showed higher inhibitory activity against α-glucosidase than commercially available diphenhydramine hydrochloride. Moreover, two of them, (66.9%) and (64.2%), had a greater inhibitory activity than the reference drug acarbose (51.8%). The hematopoietic activity was studied in albino laboratory female rats (in vivo). The compounds , , and can restore immune blood cells (hematopoietic activity), equal to or exceeding that of the commercially available diphenhydramine hydrochloride and control (methyluracil).
本研究介绍了基于2-(二苯基甲氧基)-N,N-二甲基乙胺（苯海拉明）的离子化合物的合成及其抗糖尿病和造血活性。合成是在超声（US）和微波（MW）辐射下以及使用传统方法（热活化）进行的。根据对α-葡萄糖苷酶和α-淀粉酶的抑制作用（体外）对合成的离子化合物进行了抗糖尿病作用测试。所有合成的苯海拉明衍生物对α-葡萄糖苷酶的抑制活性均高于市售盐酸苯海拉明。此外，其中两种化合物，（66.9%）和（64.2%），具有比参考药物阿卡波糖（51.8%）更高的抑制活性。在白化病实验雌性大鼠体内研究了造血活性。化合物、和可以恢复免疫血细胞（造血活性），等于或超过市售盐酸苯海拉明和对照（甲基尿嘧啶）。
