Lakkakula Jaya, Mallick Geetanjali, Das Chinmay, Uddin Imran
Amity Institute of Biotechnology, Amity University Maharashtra, Mumbai-Pune Expressway, Bhatan, Panel, Mumbai, Maharashtra 410206, India; Centre for Computational Biology and Translational Research, Amity University Maharashtra, Mumbai-Pune Expressway, Bhatan, Panel, Mumbai, Maharashtra 410206, India.
Amity Institute of Biotechnology, Amity University Maharashtra, Mumbai-Pune Expressway, Bhatan, Panel, Mumbai, Maharashtra 410206, India.
Carbohydr Polym. 2025 Oct 15;366:123793. doi: 10.1016/j.carbpol.2025.123793. Epub 2025 May 23.
Cyclodextrin-enhanced photothermal therapy (CD-PTT) has become a potential technique for both cancer diagnostics and treatment. CD-PTT provides a novel strategy to improve cancer treatments' specificity and efficacy by exploiting cyclodextrins' unique capacity to form inclusion complexes with diverse therapeutic drugs and photothermal conversion materials. This study presents a detailed overview of recent improvements in CD-PTT, emphasizing their role in increasing photothermal agent bioavailability, stability, and targetability. The promise of these systems in imaging-guided treatment and their ability to reduce off-target effects presents CD-PTT as a strong weapon in the battle against cancer. PTT has evolved as a novel approach that can replace or be used in conjunction with conventional methods such as chemotherapy and immunotherapy. Cyclodextrins have several properties that have rendered them valuable in cancer diagnosis and treatment, including complex formation, enhanced targeting, formation, enhanced targeting, biocompatibility, regulated release, etc. This study examines certain CD-PTT developments for malignancies such as breast, cervical, lung, melanoma, liver, and colon cancer. The fundamental concepts of PTT are applied to these malignant cell lines, which entails increasing the temperature of the tumours, and producing apoptosis, while more research is performed to optimize the approach for better detection and therapy.
环糊精增强光热疗法(CD-PTT)已成为一种用于癌症诊断和治疗的潜在技术。CD-PTT通过利用环糊精与多种治疗药物和光热转换材料形成包合物的独特能力,为提高癌症治疗的特异性和疗效提供了一种新策略。本研究详细概述了CD-PTT的最新进展,强调了它们在提高光热剂生物利用度、稳定性和靶向性方面的作用。这些系统在成像引导治疗中的前景以及它们减少脱靶效应的能力,使CD-PTT成为对抗癌症的有力武器。光热疗法已发展成为一种可以替代传统方法(如化疗和免疫疗法)或与之联合使用的新方法。环糊精具有多种特性,使其在癌症诊断和治疗中具有重要价值,包括形成复合物、增强靶向性、生物相容性、控释等。本研究考察了针对乳腺癌、宫颈癌、肺癌、黑色素瘤、肝癌和结肠癌等恶性肿瘤的某些CD-PTT进展。光热疗法的基本概念应用于这些恶性细胞系,这需要提高肿瘤温度并诱导细胞凋亡,同时还需要进行更多研究以优化该方法,以实现更好的检测和治疗。