给大鼠喂食缺锌饮食对味觉敏锐度和舌上皮的影响。

The effects of feeding a zinc-deficient diet on taste acuity and tongue epithelium in rats.

作者信息

Catalanotto F A, Nanda R

出版信息

J Oral Pathol. 1977 Jul;6(4):211-20. doi: 10.1111/j.1600-0714.1977.tb01643.x.

DOI:10.1111/j.1600-0714.1977.tb01643.x

Abstract

Taste preferences, fluid intake and histology of tongue epithelium were studied in rats fed a zinc-deficient diet and in pair-fed controls. The results of two-bottle preference tests demonstrated that zinc-deficient rats exhibited significantly increased preferences for 1.5 X 10(-1) M HCL and 1.28 X 10(-6) M quinine sulfate as well as a significant increase in relative fluid volume intake. Histologic examination of the tongue epithelium of the zinc-deficient rats showed a hypercellular prickle cell layer and a marked parakeratosis. The fungiform papillae of the zinc-deficient rats exhibited acanthosis and mild parakeratosis. However, the pore region of the taste buds did not seem to be covered by the parakeratotic epithelium. The results suggest that the impaired taste observed in zinc-deficient rats may not be related to blockage of tastants from the pore region.

摘要

对喂食缺锌饮食的大鼠和配对喂食的对照大鼠的味觉偏好、液体摄入量和舌上皮组织学进行了研究。双瓶偏好测试结果表明，缺锌大鼠对1.5×10⁻¹M盐酸和1.28×10⁻⁶M硫酸奎宁的偏好显著增加，相对液体摄入量也显著增加。对缺锌大鼠舌上皮的组织学检查显示棘细胞层细胞增多和明显的不全角化。缺锌大鼠的菌状乳头表现为棘皮症和轻度不全角化。然而，味蕾的孔区域似乎没有被不全角化上皮覆盖。结果表明，在缺锌大鼠中观察到的味觉受损可能与孔区域的味觉物质受阻无关。