Crane Meredith J, McKinney Robin L, Jordon Alexander R D, Eberson Craig P, Jamieson Amanda M
Department of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island, USA.
Division of Pediatric Critical Care, Hasbro Children's Hospital and the Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Wound Repair Regen. 2025 Jul-Aug;33(4):e70076. doi: 10.1111/wrr.70076.
This study examines immune and inflammatory responses in draining wound fluid over the course of the early stages of wound healing in patients recovering from spinal fusion surgery. The inflammatory phase of wound healing is essential for setting the stage for successful tissue repair and preventing chronic or poorly healing wounds. Scoliosis can be idiopathic or occur secondary to neuromuscular disorders, which are known to be associated with poor wound healing outcomes. We hypothesised that neuromuscular scoliosis patients would exhibit differences in inflammatory wound healing markers compared to idiopathic scoliosis patients. Comparison of the cellular and cytokine contents of draining wound fluid revealed that several inflammatory cytokines were elevated in the neuromuscular scoliosis patient group compared to idiopathic, whereas the leukocyte contents were the same between groups. This study shows that draining wound fluid is a good source of cellular and soluble biomarkers for acute wound healing and can be used to determine changes in individuals at risk for wound healing complications.
本研究调查了脊柱融合手术康复患者伤口愈合早期引流伤口液中的免疫和炎症反应。伤口愈合的炎症阶段对于为成功的组织修复奠定基础以及预防慢性或愈合不良的伤口至关重要。脊柱侧弯可能是特发性的，也可能继发于神经肌肉疾病，已知这些疾病与伤口愈合不良的结果相关。我们假设，与特发性脊柱侧弯患者相比，神经肌肉性脊柱侧弯患者在炎症伤口愈合标志物方面会表现出差异。对引流伤口液的细胞和细胞因子含量进行比较后发现，与特发性脊柱侧弯患者相比，神经肌肉性脊柱侧弯患者组中的几种炎症细胞因子有所升高，而两组之间的白细胞含量相同。本研究表明，引流伤口液是急性伤口愈合中细胞和可溶性生物标志物的良好来源，可用于确定有伤口愈合并发症风险个体的变化。
