Chen Xiaoya, Huo Xiongwei, Ye Changchun, Xu Zhengshui, Chen Zilu, Liu Shiyuan
Department of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Front Aging. 2025 Jul 15;6:1621107. doi: 10.3389/fragi.2025.1621107. eCollection 2025.
The Oxidative Balance Score (OBS) serves as a means to evaluate the systemic oxidative stress status, where the higher OBS score indicates a greater exposure to antioxidants. Few studies have delved into the connection between the systemic oxidative stress status and gallstone.
A total of 4,376 from the NHANES participants were included in this cross-sectional analysis using 2017-2020 survey cycles. Gallstone was diagnosed by the Patient Health Questionnaire. OBS was scored by 16 dietary factors and 4 lifestyle factors. Logistic regression, subgroup analysis and restricted cubic splines (RCS) were used to assess the association between OBS and gallstone.
In a sample comprising 4,376 individuals, logistic regression illuminated a negative association between OBS and gallstone [OR = 0.96 (0.94, 0.98), p < 0.001]. Compared to the lowest quartile of OBS, the fully adjusted ORs for the highest quartile of total OBS and gallstone were 0.65 (0.45, 0.95), p=0.025. Robust associations were also discerned between gallstone and both dietary and lifestyle OBS. The results of the subgroup analysis showed significant differences in the association between lifestyle OBS and gallstone with respect to age and marital status. RCS analysis indicated a significant linear relationship between OBS and gallstone.
Our study exhibited a reverse relationship between OBS and the prevalence of gallstone among American adults, which provided a theoretical foundation for designing personalized dietary regimens and lifestyle modifications to mitigate gallstone formation.
氧化平衡评分（OBS）是评估全身氧化应激状态的一种方法，OBS评分越高表明抗氧化剂暴露量越大。很少有研究深入探讨全身氧化应激状态与胆结石之间的联系。
本横断面分析纳入了2017 - 2020年调查周期的4376名美国国家健康与营养检查调查（NHANES）参与者。通过患者健康问卷诊断胆结石。OBS由16种饮食因素和4种生活方式因素评分。采用逻辑回归、亚组分析和受限立方样条（RCS）来评估OBS与胆结石之间的关联。
在一个包含4376人的样本中，逻辑回归表明OBS与胆结石之间存在负相关[比值比（OR）= 0.96（0.94，0.98），p < 0.001]。与OBS最低四分位数相比，总OBS最高四分位数与胆结石的完全调整后OR为0.65（0.45，0.95），p = 0.025。在胆结石与饮食和生活方式OBS之间也发现了显著关联。亚组分析结果显示，生活方式OBS与胆结石之间的关联在年龄和婚姻状况方面存在显著差异。RCS分析表明OBS与胆结石之间存在显著的线性关系。
我们的研究显示美国成年人中OBS与胆结石患病率之间存在反向关系，这为设计个性化饮食方案和生活方式调整以减轻胆结石形成提供了理论基础。
